سعر ميبادرينال 50 كربوله 2023

Mepadrenal (Alexandria, Egypt): dental local anaesthetic cartridges, each 1.8 ml containing mepivacaine 36 mg (2%) and adrenaline 0.018 mg (1:100,000); box of 50 cartridges.

• Local (dental) anaesthesia for oral surgery and dental procedures requiring prolonged anaesthesia and haemostasis.Population: Adults and children aged 3 years and overMedsafe (New Zealand Medicines and Medical Devices Safety Authority)

• Local reactions at the injection site, headache, paraesthesia; systemic toxicity (CNS excitation then depression, convulsions; cardiovascular depression, bradycardia, arrhythmias, hypotension or hypertension from adrenaline) mainly with overdose or accidental intravascular injection; allergic reactions including to sulfites.International label, equivalent formulation · Medsafe (New Zealand Medicines and Medical Devices Safety Authority)

• Hypersensitivity to amide-type local anaesthetics, adrenaline or any excipient; hypersensitivity to sulfites (the solution contains metabisulfite).International label, equivalent formulation · Medsafe (New Zealand Medicines and Medical Devices Safety Authority)
• Cerebral arteriosclerosis, hypertension, coronary or valvular heart disease, and untreated thyrotoxicosis (adrenaline-containing solution).International label, equivalent formulation · Medsafe (New Zealand Medicines and Medical Devices Safety Authority)
• Intravenous injection; inflammation or sepsis in the region of injection; patients receiving MAO inhibitors (or within two weeks of them) or tricyclic antidepressants; patients in whom general anaesthesia might be required to complete the procedure.International label, equivalent formulation · Medsafe (New Zealand Medicines and Medical Devices Safety Authority)

• Use with caution in hepatic or renal disease, epilepsy, bradycardia, heart block and in debilitated, elderly or acutely ill patients and children (dose adjusted to status); because of the adrenaline, not advised in diabetic subjects and to be used with extreme caution in severe cardiovascular disease or thyrotoxicosis. Inject slowly after aspiration to avoid intravascular injection; resuscitation equipment and drugs must be immediately available. Warn patients to avoid biting lips/tongue while numb.International label, equivalent formulation · Medsafe (New Zealand Medicines and Medical Devices Safety Authority)

• MAO inhibitors, tricyclic antidepressants and phenothiazinesAdrenaline-containing local anaesthetics may produce severe, prolonged hypertension or hypotension in these patients; MAOI/TCA use is a contraindication per the data sheet.Medsafe (New Zealand Medicines and Medical Devices Safety Authority)
• Beta-adrenergic blockers (e.g. propranolol, timolol)May result in dose-dependent hypertension with adrenaline; propranolol and metoprolol may also reduce mepivacaine metabolism.Medsafe (New Zealand Medicines and Medical Devices Safety Authority)
• Oral hypoglycaemic agents / insulinAdrenaline may raise blood glucose and reduce the effect of glucose-lowering drugs.Medsafe (New Zealand Medicines and Medical Devices Safety Authority)

• Pregnancy Category A (Australian categorisation, as stated in the NZ data sheet). The safe use of mepivacaine in pregnancy has not been established, but it has been used extensively for dental procedures during pregnancy with no proven increase in malformations or harmful effects to mother or foetus; adrenaline has been given to many pregnant women without proven harm.International label, equivalent formulation · Medsafe (New Zealand Medicines and Medical Devices Safety Authority)
• It is not known whether mepivacaine or its metabolites appear in breast milk; adrenaline is excreted in breast milk. Use is therefore not recommended during lactation.International label, equivalent formulation · Medsafe (New Zealand Medicines and Medical Devices Safety Authority)

• Mepivacaine: Amide-type local anaesthetic that reversibly blocks nerve impulse conduction (NZ data sheet).
• Adrenaline (epinephrine): Vasoconstrictor that reduces local blood flow, delaying absorption and prolonging the local anaesthetic effect and providing haemostasis (NZ data sheet).