سعر ميثيل فوليت اوركيديا 30 كبسولة 2026

Methyl Folate capsules (Orchidia Pharmaceutical Industries), each providing 5-MTHF (L-methylfolate) 800 mcg and methylcobalamin 1000 mcg; 30 capsules; food supplement (gluten- and dairy-free per manufacturer).

• High folate intakes can correct the megaloblastic anaemia but not the neurological damage of vitamin B12 deficiency, and large amounts may precipitate or exacerbate the anaemia and cognitive symptoms of B12 deficiency.General active-ingredient information · NIH Office of Dietary Supplements
• Vitamin B12 has no tolerable upper intake level because of its low potential for toxicity; it is generally considered safe even at high doses.General active-ingredient information · NIH Office of Dietary Supplements

• MethotrexateFolate antagonist: patients taking methotrexate for cancer should consult their oncologist before taking folate supplements (may interfere with anticancer effect); folate may reduce gastrointestinal side effects of low-dose methotrexate for rheumatoid arthritis or psoriasis.NIH Office of Dietary Supplements
• MetforminMetformin may reduce the absorption of vitamin B12 and significantly reduce serum B12 concentrations.NIH Office of Dietary Supplements
• Gastric acid inhibitors (proton pump inhibitors, H2-receptor antagonists)May interfere with vitamin B12 absorption from food.NIH Office of Dietary Supplements

• Folate requirements increase in pregnancy; the CDC recommends 400 mcg/day of folic acid (not 5-MTHF) for people who could become pregnant, even with an MTHFR 677C>T polymorphism.General active-ingredient information · NIH Office of Dietary Supplements

• L-Methylfolate (5-methyltetrahydrofolate): 5-MTHF is the main form of folate in plasma; supplements may contain it instead of folic acid (NIH ODS).
• Methylcobalamin (mecobalamin): Methylcobalamin and 5-deoxyadenosylcobalamin are the metabolically active forms of vitamin B12, which acts as a cofactor for methionine synthase (conversion of homocysteine to methionine) and L-methylmalonyl-CoA mutase (NIH ODS).