سعر الفانوفا بلس نقط للعين 5 مل 2024

Egyptian fixed-combination eye drops of brimonidine and timolol (5 ml) by Orchidia, used to lower raised intraocular pressure.

• Reduction of elevated intraocular pressure in glaucoma or ocular hypertension needing adjunctive or replacement therapyPopulation: Adults and children 2 years and older (US label)DailyMed (NLM)

• Most common (about 5-15%): allergic conjunctivitis, conjunctival folliculosis, conjunctival hyperaemia, eye itching, ocular burning and stinging.International label, equivalent formulation · DailyMed (NLM)
• 1-5%: dry mouth, somnolence, headache, asthenia, eye dryness/pain/discharge, eyelid oedema or erythema, blurred/visual disturbance, superficial punctate keratitis, hypertension, depression.International label, equivalent formulation · DailyMed (NLM)

• Reactive airway disease including bronchial asthma or a history of it, and severe COPD.International label, equivalent formulation · DailyMed (NLM)
• Sinus bradycardia, second- or third-degree AV block, overt cardiac failure, cardiogenic shock.International label, equivalent formulation · DailyMed (NLM)
• Neonates and infants under 2 years.International label, equivalent formulation · DailyMed (NLM)

• Timolol is absorbed systemically: severe respiratory (bronchospasm) and cardiac reactions, including deaths, have been reported; may precipitate cardiac failure.International label, equivalent formulation · DailyMed (NLM)
• Beta-blockade may mask hypoglycaemia in diabetics and signs of thyrotoxicosis, worsen myasthenic weakness, and blunt response to epinephrine in anaphylaxis.International label, equivalent formulation · DailyMed (NLM)
• Use with caution in depression, cerebral/coronary insufficiency, Raynaud phenomenon, orthostatic hypotension; ocular hypersensitivity reactions possible; review before major surgery.International label, equivalent formulation · DailyMed (NLM)

• Antihypertensives / cardiac glycosidesAdditive blood-pressure lowering; use with caution.DailyMed (NLM)
• Systemic beta-blockersAdditive systemic and intraocular beta-blockade; two topical beta-blockers not recommended.DailyMed (NLM)
• Oral or IV calcium channel blockers; digitalisRisk of AV conduction disturbance, left ventricular failure and hypotension; avoid in impaired cardiac function.DailyMed (NLM)

• No adequate studies in pregnant women; available human data insufficient to establish a drug-associated risk. Oral animal studies at high multiples of the ophthalmic dose showed no adverse developmental effects.International label, equivalent formulation · DailyMed (NLM)
• Timolol is found in human milk; brimonidine is excreted in animal milk. Not recommended during breastfeeding because of possible serious infant reactions (CNS depression, apnoea).International label, equivalent formulation · DailyMed (NLM)

• Brimonidine: Alpha-2 adrenergic agonist that lowers intraocular pressure by reducing aqueous humor production and increasing uveoscleral outflow (US Alphagan P label).
• Timolol: Non-selective beta1/beta2 blocker; lowers intraocular pressure by reducing aqueous humor formation (US Combigan label).