سعر ميثيل دوبا 250 مجم 30 قرص 2024

Methyldopa 250 mg film-coated tablets, 30 per pack (Alexandria Company for Pharmaceuticals), a centrally acting alpha-2 agonist antihypertensive.

• HypertensionPopulation: Adults and paediatric patientsDailyMed (U.S. National Library of Medicine)

• Sedation (usually transient) at the start of therapy or when the dose is increased; headache, asthenia or weakness early in treatment; also reported: orthostatic hypotension, oedema or weight gain, bradycardia, aggravation of angina, nausea, vomiting, diarrhoea, pancreatitis and colitis.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Active hepatic disease (such as acute hepatitis or active cirrhosis); liver disorders previously associated with methyldopa; hypersensitivity to any component; therapy with monoamine oxidase (MAO) inhibitors.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• A positive direct Coombs test develops in 10% to 20% of patients on prolonged therapy; haemolytic anaemia and liver disorders (which may be fatal if unrecognised) can occur. Perform blood counts, Coombs test and liver function tests before and periodically during therapy.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• LithiumMonitor carefully for lithium toxicity when given together.DailyMed (U.S. National Library of Medicine)
• Ferrous sulfate or ferrous gluconateDecrease the bioavailability of methyldopa and may impair blood pressure control.DailyMed (U.S. National Library of Medicine)
• Other antihypertensive drugs and anaestheticsAdditive hypotensive effect; doses of other antihypertensives may need adjustment, and anaesthetic requirements may be reduced.DailyMed (U.S. National Library of Medicine)

• Animal studies showed no evidence of fetal harm; there are no adequate well-controlled first-trimester studies, so use only if clearly needed. Published reports of use in all trimesters indicate that the possibility of fetal harm appears remote.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Methyldopa appears in breast milk; use with caution in nursing women.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Methyldopa: Its antihypertensive effect is probably due to metabolism to alpha-methylnorepinephrine, which lowers arterial pressure by stimulating central inhibitory alpha-adrenergic receptors, false neurotransmission and/or reduction of plasma renin activity (US label).