سعر مياكالسيك 200وحدة/مل سبراي للانف 2 مل 2024

Calcitonin (salmon) nasal spray, 2 ml bottle, labelled "200 i.u./ml" in Egyptian directories (Miacalcic, Novartis).

• In postmenopausal osteoporosis trials (at least 3% of patients): rhinitis 12%, other nasal symptoms 11%, back pain 5%, arthralgia 4%, epistaxis 4%, headache 3%.International label, equivalent formulation · DailyMed (US National Library of Medicine)

• Hypersensitivity to calcitonin salmon or any excipient (anaphylactic shock, anaphylaxis, bronchospasm, tongue or throat swelling reported).International label, equivalent formulation · DailyMed (US National Library of Medicine)

• Serious hypersensitivity reactions; consider skin testing in suspected sensitivity.International label, equivalent formulation · DailyMed (US National Library of Medicine)
• Hypocalcaemia with tetany and seizures has been reported; correct hypocalcaemia before starting.International label, equivalent formulation · DailyMed (US National Library of Medicine)
• Nasal adverse reactions (rhinitis, epistaxis, mucosal changes); examine the nasal mucosa before and periodically during treatment; stop if severe ulceration occurs.International label, equivalent formulation · DailyMed (US National Library of Medicine)
• Malignancy: a meta-analysis of 21 trials found more malignancies with calcitonin salmon (4.1%) than placebo (2.9%); periodically re-evaluate the need for continued therapy.International label, equivalent formulation · DailyMed (US National Library of Medicine)
• Circulating antibodies may develop; consider this if an initial response is lost.International label, equivalent formulation · DailyMed (US National Library of Medicine)
• EMA (July 2012): because long-term calcitonin use was associated with an increased cancer risk (0.7-2.4% higher than placebo, higher with intranasal calcitonin), calcitonin nasal spray should no longer be prescribed for osteoporosis in the EU and the intranasal formulation was recommended for withdrawal.International label, equivalent formulation · European Medicines Agency (EMA)

• US label: not indicated for females of reproductive potential; no data in pregnant women; reduced fetal birth weight in rabbits at high parenteral doses.International label, equivalent formulation · DailyMed (US National Library of Medicine)
• US label: no information on presence in human milk; calcitonin inhibited lactation in rats.International label, equivalent formulation · DailyMed (US National Library of Medicine)

• Periodic nasal examinations (before treatment, periodically and whenever nasal symptoms occur); periodic urine sediment examination may be considered.International label, equivalent formulation · DailyMed (US National Library of Medicine)

• Calcitonin (salmon): Acts primarily on bone; decreases the rate of bone resorption, associated with fewer osteoclasts and reduced resorptive activity (calcitonin receptors are present on osteoclasts and osteoblasts) (US label).