سعر ميوكوسيكلين اس.ار. 10كبسولات 2022

Mucocycline S.R. capsules (Unipharma): combination of the tetracycline antibiotic doxycycline with the mucolytic ambroxol, sustained-release, box of 10 capsules.

• Gastrointestinal effects (anorexia, nausea, vomiting, diarrhoea, glossitis, dysphagia, enterocolitis), rare oesophagitis/oesophageal ulceration, rare hepatotoxicity, skin reactions and photosensitivity.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to any of the tetracyclines.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Tetracyclines during tooth development (last half of pregnancy, infancy and childhood up to 8 years) may cause permanent yellow-grey-brown tooth discoloration and enamel hypoplasia; use in children ≤8 years only when benefits outweigh risks in severe conditions.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Clostridioides difficile-associated diarrhoea, photosensitivity and overgrowth of non-susceptible organisms can occur.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Severe skin reactions (erythema multiforme, Stevens-Johnson syndrome/toxic epidermal necrolysis, acute generalised exanthematous pustulosis) have been reported with ambroxol; stop treatment immediately and seek medical advice if a progressive rash (sometimes with blisters or mucosal lesions) appears.General active-ingredient information · Fachinfo-Service (Rote Liste Service GmbH)

• Antacids containing aluminium, calcium or magnesium; iron preparations; bismuth subsalicylateImpair the absorption of tetracyclines.DailyMed (U.S. National Library of Medicine)
• Oral anticoagulantsTetracyclines can depress plasma prothrombin activity; anticoagulant dose may need reduction.DailyMed (U.S. National Library of Medicine)
• PenicillinBacteriostatic tetracyclines may interfere with the bactericidal action of penicillin; avoid the combination.DailyMed (U.S. National Library of Medicine)
• Barbiturates, carbamazepine, phenytoin; oral contraceptivesEnzyme inducers shorten the half-life of doxycycline; tetracyclines may render oral contraceptives less effective.DailyMed (U.S. National Library of Medicine)
• Antitussives (cough suppressants)Combined use with antitussives can cause dangerous accumulation of secretions because the cough reflex is reduced; combine only after careful benefit-risk assessment.Fachinfo-Service (Rote Liste Service GmbH)
• Antibiotics (amoxicillin, cefuroxime, erythromycin, doxycycline)After ambroxol, concentrations of these antibiotics in sputum and bronchial secretions increase; a clinical relevance has not been established.Fachinfo-Service (Rote Liste Service GmbH)

• Tetracyclines are excreted in human milk; short-term use is not necessarily contraindicated, but effects of prolonged exposure are unknown; decide whether to stop nursing or the drug.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Ambroxol: Increases the serous fraction of bronchial secretions, stimulates surfactant production by type II pneumocytes and Clara cells and stimulates ciliary activity, lowering mucus viscosity and improving mucociliary clearance.
• Doxycycline: Primarily bacteriostatic; inhibits bacterial protein synthesis by binding the 30S ribosomal subunit.