سعر نافيلوكا 2مجم/مل فيال 25مل 2022

Naviluca 2 mg/ml IV infusion vial 25 ml (Arabcomed-Egypt > Rotabiogen, Egypt): fluconazole 2 mg/ml solution for intravenous infusion.

• IV fluconazole is indicated for treatment of candidemia and other systemic candidal infections, cryptococcal meningitis, and other serious fungal infections as labeled; also for prophylaxis in certain immunocompromised patients (US injection / UK SmPC).Population: AdultsDailyMed / FDA, electronic medicines compendium (emc), UK

• Nausea, headache, rash, abdominal pain, diarrhoea, elevated hepatic enzymes; IV infusion may cause local reactions.International label, same formulation · DailyMed / FDA

• Hypersensitivity to fluconazole or other azoles; contraindicated combinations with certain QT-prolonging CYP3A4 substrates as in oral fluconazole labeling.International label, same formulation · DailyMed / FDA

• Hepatotoxicity; QT prolongation; anaphylaxis; embryo-fetal toxicity with high-dose use in pregnancy.International label, same formulation · DailyMed / FDA

• WarfarinMajorMay potentiate anticoagulant effect; monitor INR.DailyMed / FDA
• CYP3A4/CYP2C9 substratesMajorFluconazole inhibits CYP enzymes; many significant interactions.DailyMed / FDA

• Chronic high-dose fluconazole in first trimester associated with a pattern of congenital anomalies; use in pregnancy only if clearly needed for severe infection.International label, same formulation · DailyMed / FDA
• Fluconazole present in human milk; weigh clinical need vs breastfeeding (US label).International label, same formulation · DailyMed / FDA

• Fluconazole: Inhibits fungal cytochrome P-450-mediated 14-alpha-lanosterol demethylation, an essential step in ergosterol biosynthesis; more selective for fungal than mammalian cytochrome P-450 enzymes (UK Diflucan SmPC, section 5.1).