سعر امريفلوكان 50مجم 7 كبسولة 2022

Fluconazole 50 mg capsules, pack of 7; triazole antifungal.

• Adults: cryptococcal meningitis; coccidioidomycosis; invasive candidiasisPopulation: Adultselectronic medicines compendium (emc), UK
• Adults: mucosal candidiasis (oropharyngeal, oesophageal, candiduria, chronic mucocutaneous), chronic oral atrophic candidiasis, acute or recurrent vaginal candidiasis and candidal balanitis when local therapy is not appropriatePopulation: Adultselectronic medicines compendium (emc), UK
• Adults: dermatomycosis (tinea pedis, corporis, cruris, versicolor, dermal candida infections) when systemic therapy is indicated, and tinea unguium (onychomycosis) when other agents are not appropriatePopulation: Adultselectronic medicines compendium (emc), UK

• Most frequent (1-10%): headache, abdominal pain, diarrhoea, nausea, vomiting, increased ALT, AST and alkaline phosphatase, and rash; DRESS has been reported.International label, equivalent formulation · electronic medicines compendium (emc), UK

• Hypersensitivity to fluconazole, related azoles or any excipient; coadministration with terfenadine at fluconazole doses of 400 mg/day or more; coadministration with QT-prolonging CYP3A4 substrates such as cisapride, astemizole, pimozide, quinidine and erythromycin.International label, equivalent formulation · electronic medicines compendium (emc), UK

• Rare serious hepatotoxicity, including fatalities (mainly in patients with serious underlying conditions); monitor patients who develop abnormal liver tests and stop treatment if signs of serious hepatic injury (asthenia, anorexia, persistent nausea, vomiting, jaundice) appear.International label, equivalent formulation · electronic medicines compendium (emc), UK
• QT prolongation and rare torsades de pointes; use with caution in potentially proarrhythmic conditions (e.g., hypokalaemia, advanced heart failure); halofantrine is not recommended.International label, equivalent formulation · electronic medicines compendium (emc), UK
• Rare exfoliative skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis) and DRESS; rare anaphylaxis; possible adrenal insufficiency; moderate CYP2C9/CYP3A4 and strong CYP2C19 inhibitor - monitor narrow-therapeutic-index co-medications; increasing prevalence of resistant non-albicans Candida (C. krusei, C. auris, C. glabrata); not for tinea capitis; capsules contain lactose.International label, equivalent formulation · electronic medicines compendium (emc), UK

• Cisapride, astemizole, pimozide, quinidine, erythromycinContraindicated: risk of QT prolongation and torsades de pointes.electronic medicines compendium (emc), UK
• TerfenadineContraindicated with fluconazole 400 mg/day or more; carefully monitor at lower doses.electronic medicines compendium (emc), UK
• HalofantrineIncreased halofantrine levels and cardiotoxicity risk; avoid the combination.electronic medicines compendium (emc), UK

• Observational studies suggest an increased risk of spontaneous abortion with fluconazole in the first and/or second trimester; cumulative doses of 150 mg or less in the first trimester did not increase overall malformation risk, while prolonged high doses (400-800 mg/day) have been associated with a pattern of birth defects. Standard short courses should not be used in pregnancy unless clearly necessary; high-dose or prolonged regimens only for potentially life-threatening infections.International label, equivalent formulation · electronic medicines compendium (emc), UK
• Women of childbearing potential: after a single dose, a 1-week washout is recommended before becoming pregnant; for longer courses, contraception may be considered during treatment and for 1 week after the last dose.International label, equivalent formulation · electronic medicines compendium (emc), UK
• Fluconazole passes into breast milk at concentrations similar to plasma; breastfeeding may continue after a single 150 mg dose but is not recommended after repeated or high-dose use.International label, equivalent formulation · electronic medicines compendium (emc), UK

• Fluconazole: Inhibits fungal cytochrome P-450-mediated 14-alpha-lanosterol demethylation, an essential step in ergosterol biosynthesis; more selective for fungal than mammalian cytochrome P-450 enzymes (UK Diflucan SmPC, section 5.1).