سعر نيوفلور 250مجم/5مل 5 امبول 2022

Fluorouracil 250 mg/5 ml (50 mg/mL) concentrate for IV solution, box of 5 ampoules. Manufactured by Cipla (India), marketed in Egypt by Star International. Cytotoxic chemotherapy agent.

• US label: fluorouracil is indicated for adenocarcinoma of the colon and rectum, breast, gastric adenocarcinoma, and pancreatic adenocarcinoma (Fresenius DailyMed).Population: Adults (chemotherapy protocols)DailyMed / Fresenius Kabi

• BOXED WARNING (US): Serious adverse reactions or death may occur in patients with complete DPD deficiency. Test for DPYD variants before initiating unless immediate treatment is necessary; avoid in complete DPD deficiency (Fresenius DailyMed).International label, same formulation · DailyMed / Fresenius Kabi
• Cardiotoxicity, hyperammonemic encephalopathy, neurologic toxicity, severe diarrhea, hand-foot syndrome, myelosuppression, mucositis; elevated INR with warfarin; embryofetal toxicity (Fresenius DailyMed).International label, same formulation · DailyMed / Fresenius Kabi

• Warfarin / coumarin anticoagulantsMajorClinically significant elevations in coagulation parameters with concomitant fluorouracil; monitor INR/PT closely (Fresenius DailyMed).DailyMed / Fresenius Kabi

• US label: can cause fetal harm; advise effective contraception during and for 3 months after therapy. Historical Pregnancy Category D language also present on label (Fresenius DailyMed).International label, same formulation · DailyMed / Fresenius Kabi
• US label: discontinue nursing or discontinue the drug because of potential serious adverse reactions in nursing infants (Fresenius DailyMed).International label, same formulation · DailyMed / Fresenius Kabi

• Fluorouracil: Inhibits thymidylate synthase after intracellular activation, disrupting DNA synthesis in rapidly dividing cells.