سعر نبيرالين 200مجم 10 اقراص 2022

Nevirapine 200 mg tablets (10), a non-nucleoside reverse transcriptase inhibitor used in combination antiretroviral therapy for HIV-1, by EGPI (Egypt).

• Treatment of HIV-1 infection in combination with other antiretroviral agents in adults and pediatric patients 15 days and older; not recommended to be initiated in adult females with CD4+ >250 cells/mm3 or adult males with CD4+ >400 cells/mm3 unless benefit outweighs riskPopulation: Adults and pediatric patients >=15 daysDailyMed (US National Library of Medicine)

• Most common: rash (adults 15% vs 6% placebo; grade 3/4 in 2%); in pediatric subjects rash 21%. Most serious: hepatitis/hepatic failure, SJS/TEN and hypersensitivity reactions.International label, equivalent formulation · DailyMed (US National Library of Medicine)

• Moderate or severe (Child-Pugh B or C) hepatic impairment.International label, equivalent formulation · DailyMed (US National Library of Medicine)
• Use as part of occupational or non-occupational post-exposure prophylaxis (PEP) regimens.International label, equivalent formulation · DailyMed (US National Library of Medicine)

• BOXED WARNING: severe, life-threatening and sometimes fatal hepatotoxicity, especially in the first 18 weeks; women and patients with higher CD4+ counts at initiation (women >250 cells/mm3, including pregnant women) are at greatest risk.International label, equivalent formulation · DailyMed (US National Library of Medicine)
• BOXED WARNING: severe, life-threatening skin reactions (including Stevens-Johnson syndrome, toxic epidermal necrolysis) and hypersensitivity reactions; permanently discontinue if severe rash or rash with systemic symptoms occurs.International label, equivalent formulation · DailyMed (US National Library of Medicine)
• Monitor for immune reconstitution syndrome and fat redistribution.International label, equivalent formulation · DailyMed (US National Library of Medicine)

• Drugs metabolised by CYP3A and CYP2B6Nevirapine induces CYP3A and CYP2B6; co-administered drugs metabolised by these enzymes may have lower plasma levels (see label tables for dose adjustments).DailyMed (US National Library of Medicine)

• US label: Antiretroviral Pregnancy Registry data show no difference in overall major birth defects versus the 2.7% background rate; hepatotoxicity risk is greatest in women with CD4+ >250 cells/mm3, including pregnant women.International label, equivalent formulation · DailyMed (US National Library of Medicine)
• Nevirapine is present in human milk; because of the risk of HIV-1 transmission, viral resistance and serious adverse reactions in the infant, mothers receiving nevirapine should not breastfeed (US label/CDC).International label, equivalent formulation · DailyMed (US National Library of Medicine)

• Nevirapine: Binds directly to HIV-1 reverse transcriptase and blocks its RNA- and DNA-dependent DNA polymerase activity; induces CYP3A and CYP2B6.