سعر نورميسار بلس 20/12.5مجم 10 اقراص 2022

Egyptian olmesartan medoxomil 20 mg + hydrochlorothiazide 12.5 mg film-coated tablets, pack of 10 (Jedco / Four A Pharma).

• Hypertension (when combination therapy appropriate)Population: AdultsDailyMed (U.S. NLM)

• Hypersensitivity to olmesartan, hydrochlorothiazide, other sulfonamide-derived drugs, or excipients; anuria; pregnancy (2nd/3rd trimester for ARB component). Do not co-administer aliskiren in diabetes.International label, same formulation · DailyMed (U.S. NLM)

• Fetal toxicity from ARB component — discontinue when pregnancy detected. Volume depletion, electrolyte imbalance (hypokalaemia/hyponatraemia from HCTZ; hyperkalaemia risk from ARB), renal impairment, sprue-like enteropathy (olmesartan), photosensitivity (HCTZ).International label, same formulation · DailyMed (U.S. NLM)

• ARB + HCTZ: discontinue as soon as pregnancy is detected due to fetal toxicity of drugs acting on the renin-angiotensin system; thiazides also cross the placenta.International label, same formulation · DailyMed (U.S. NLM)

• Olmesartan medoxomil: Prodrug hydrolysed to olmesartan, which blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II at the AT1 receptor.
• Hydrochlorothiazide: Promotes renal excretion of sodium and chloride, reducing intravascular volume.