سعر نامب كريم 2022

Topical cream containing lidocaine and prilocaine (amide local anaesthetics), 50 g tube, Bio Peak, Egypt; concentrations not stated by the opened Egyptian source.

• Topical anaesthetic on normal intact skin for local analgesia, and on genital mucous membranes for superficial minor surgery and as pretreatment for infiltration anaesthesia (US label for lidocaine/prilocaine 2.5%/2.5% cream).DailyMed (U.S. National Library of Medicine)

• Known history of sensitivity to amide-type local anaesthetics or any other component of the product.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Application to larger areas or for longer times than recommended may cause sufficient systemic absorption of lidocaine and prilocaine to produce serious adverse effects.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Methemoglobinemia risk: prilocaine has been associated with methemoglobinemia; patients with G6PD deficiency, congenital or idiopathic methemoglobinemia, infants under 6 months, and those receiving oxidising agents are more susceptible.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Not recommended where penetration or migration beyond the tympanic membrane into the middle ear is possible (ototoxicity in animal studies); avoid contact with the eye.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Class III antiarrhythmics (e.g. amiodarone, bretylium, sotalol, dofetilide)Cardiac effects may be additive; keep under close surveillance and consider ECG monitoring.DailyMed (U.S. National Library of Medicine)
• Drugs associated with drug-induced methemoglobinemia (e.g. sulfonamides, acetaminophen, nitrates, nitrofurantoin, phenytoin, primaquine)Increased risk of methemoglobinemia.DailyMed (U.S. National Library of Medicine)
• Other local anaesthetics or structurally related drugs (e.g. class I antiarrhythmics such as tocainide, mexiletine)Toxic effects are additive and potentially synergistic.DailyMed (U.S. National Library of Medicine)

• Animal reproduction studies with lidocaine and prilocaine showed no fetal harm, but there are no adequate and well-controlled studies in pregnant women; use during pregnancy only if clearly needed.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Lidocaine, and probably prilocaine, are excreted in human milk; use with caution in nursing mothers.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

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