سعر اوكتوترامادول 100مجم 6 لبوس 2022

Tramadol 100 mg rectal suppositories (Octotramadol, October Pharma, Egypt); pack of 6 suppositories.

• Very common: nausea, dizziness. Common: headache, somnolence, vomiting, constipation, dry mouth, sweating, fatigue. Uncommon/rare: palpitations, tachycardia, postural hypotension, rash, respiratory depression, convulsions, hallucinations, confusion, allergic reactions; not known: serotonin syndrome, hypoglycaemia, drug dependence.General active-ingredient information · electronic medicines compendium (emc), UK

• Hypersensitivity to tramadol or excipients; acute intoxication with alcohol, hypnotics, analgesics, opioids or psychotropics; patients receiving MAO inhibitors or within 14 days of stopping them; epilepsy not adequately controlled; use in narcotic withdrawal treatment.General active-ingredient information · electronic medicines compendium (emc), UK

• Concomitant use with benzodiazepines or other sedatives may cause sedation, respiratory depression, coma and death; reserve for patients without alternatives, at the lowest dose and shortest duration.General active-ingredient information · electronic medicines compendium (emc), UK
• Convulsions can occur at recommended doses, more so above 400 mg/day or with drugs lowering the seizure threshold; use in epilepsy only if compelling.General active-ingredient information · electronic medicines compendium (emc), UK
• Tolerance, dependence and opioid use disorder can develop; abrupt stopping may cause withdrawal; agree goals and a discontinuation plan and monitor for drug-seeking behaviour.General active-ingredient information · electronic medicines compendium (emc), UK
• Serotonin syndrome may occur, especially with other serotonergic drugs.General active-ingredient information · electronic medicines compendium (emc), UK
• CYP2D6 ultra-rapid metabolisers risk opioid toxicity even at usual doses; poor metabolisers may get inadequate analgesia. Life-threatening events reported in children after tonsillectomy/adenoidectomy; not recommended in children with compromised respiratory function.General active-ingredient information · electronic medicines compendium (emc), UK
• Use with caution in opioid dependence, head injury, shock, reduced consciousness, respiratory disorders or raised intracranial pressure; may cause sleep-related breathing disorders and, occasionally, adrenal insufficiency. May impair driving.General active-ingredient information · electronic medicines compendium (emc), UK

• MAO inhibitorsContraindicated; life-threatening CNS, respiratory and cardiovascular interactions cannot be excluded.electronic medicines compendium (emc), UK
• Benzodiazepines, other CNS/respiratory depressants, alcohol, gabapentinoidsAdditive sedation, respiratory depression, hypotension, coma and death.electronic medicines compendium (emc), UK
• SSRIs, SNRIs, tricyclic antidepressants, mirtazapine and other serotonergic drugsRisk of serotonin syndrome; also increased risk of convulsions with seizure-threshold-lowering drugs (including bupropion and antipsychotics).electronic medicines compendium (emc), UK
• CarbamazepineMay reduce the analgesic effect and shorten its duration.electronic medicines compendium (emc), UK
• Coumarin anticoagulants (e.g. warfarin)Increased INR with major bleeding reported; use with caution.electronic medicines compendium (emc), UK
• CYP3A4 inhibitors (e.g. ketoconazole, erythromycin); ondansetronCYP3A4 inhibitors may inhibit tramadol metabolism; ondansetron increased tramadol requirement post-operatively.electronic medicines compendium (emc), UK

• Tramadol crosses the placenta and there is inadequate evidence of safety in human pregnancy; it should not be used in pregnant women. Regular use may cause dependence in the fetus and neonatal withdrawal; use during labour may depress neonatal respiration.General active-ingredient information · electronic medicines compendium (emc), UK
• Not recommended in nursing women, as tramadol may be secreted in breast milk and cause respiratory depression in the infant.General active-ingredient information · electronic medicines compendium (emc), UK

• Tramadol: Centrally acting analgesic; opioid (mu-receptor) activity plus inhibition of neuronal noradrenaline and serotonin reuptake; metabolised by CYP2D6 to an active metabolite (UK SmPC).