سعر اونكوفين 1جم 1فيال 2026

Oncovin vial: vincristine sulphate for intravenous use only (vinca alkaloid cytotoxic). The Egyptian listing states "1 gm"; vincristine vials are normally 1 mg/mL, so the strength needs confirmation.

• Acute leukaemia; in combination with other oncolytic agents in Hodgkin disease, non-Hodgkin lymphomas, rhabdomyosarcoma, neuroblastoma and Wilms tumour.DailyMed (U.S. National Library of Medicine)

• Most common: hair loss; most troublesome: neuromuscular effects (neuritic pain, paraesthesia); also leukopenia, constipation (including paralytic ileus), abdominal cramps, nausea and vomiting.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Patients with the demyelinating form of Charcot-Marie-Tooth syndrome.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• For intravenous use only; intrathecal administration is usually fatal. Should be diluted in a flexible plastic container labelled "for intravenous use only - fatal if given by other routes", and given by experienced personnel; avoid extravasation.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Hepatic veno-occlusive disease has been reported, particularly in paediatric patients on combination chemotherapy.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Strong CYP3A inhibitors (e.g. itraconazole) and moderate inhibitors (e.g. fluconazole)Earlier onset and/or increased severity of neuromuscular toxicity; avoid strong CYP3A inhibitors and monitor with moderate inhibitors.DailyMed (U.S. National Library of Medicine)
• PhenytoinCombination chemotherapy including vincristine reduced phenytoin levels and increased seizure activity; adjust by serial levels.DailyMed (U.S. National Library of Medicine)

• Can cause fetal harm; teratogenic and embryolethal in several animal species.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Not known whether excreted in human milk; decide whether to discontinue nursing or the drug.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Vincristine: Binds tubulin and inhibits microtubule formation, arresting cell division in metaphase.