سعر باراكالسيت 30 مجم 30 قرص 2025

Paracalcet cinacalcet 30 mg film-coated tablets, pack of 30 (3 strips), by Global Napi Pharmaceuticals (Egypt); calcimimetic.

• Secondary hyperparathyroidism in adults with chronic kidney disease on dialysis (not for CKD patients not on dialysis)Population: AdultsDailyMed (U.S. National Library of Medicine)
• Hypercalcemia in adults with parathyroid carcinomaPopulation: AdultsDailyMed (U.S. National Library of Medicine)
• Hypercalcemia in adults with primary hyperparathyroidism who cannot undergo parathyroidectomyPopulation: AdultsDailyMed (U.S. National Library of Medicine)

• Do not initiate if serum calcium is below the lower limit of normal.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypocalcemia: may cause paresthesias, myalgias, muscle spasms, seizures, QT prolongation and ventricular arrhythmia; life-threatening and fatal events reported.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Upper gastrointestinal bleeding has occurred with calcimimetics; patients with risk factors may be at increased risk.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Adynamic bone disease may develop if iPTH is suppressed below 100 pg/mL; reduce dose or stop if iPTH falls below target.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Strong CYP3A4 inhibitors (e.g. ketoconazole, itraconazole)Cinacalcet is partly metabolised by CYP3A4; dose adjustment and close monitoring of iPTH and calcium may be needed when starting or stopping these.DailyMed (U.S. National Library of Medicine)
• CYP2D6 substrates (e.g. desipramine, metoprolol, carvedilol, flecainide, tricyclic antidepressants)Cinacalcet strongly inhibits CYP2D6; dose adjustment of these drugs may be required, particularly narrow-therapeutic-index ones.DailyMed (U.S. National Library of Medicine)

• US label: limited case reports are insufficient to establish a drug-associated risk; in rats, exposure during organogenesis to weaning at 2-3 times human exposure caused peripartum and early postnatal pup loss.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• US label: no human data; cinacalcet was excreted in rat milk; weigh benefits of breastfeeding against potential infant risk.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Cinacalcet: Increases the sensitivity of the calcium-sensing receptor on parathyroid chief cells to extracellular calcium, directly lowering PTH and consequently serum calcium (US label 12.1).