سعر ارتيكو سيف 50مجم 30 كبسولة 2026

Diacerein 50 mg capsules, 30 capsules (3 strips); anthraquinone-derivative symptomatic slow-acting drug for osteoarthritis (Global Napi Pharmaceuticals).

• Symptomatic treatment with delayed action of osteoarthritis of the hip and knee.Population: AdultsBase de Données Publique des Médicaments (ANSM, France)

• Very common: diarrhoea, abdominal pain. Common: frequent bowel movements, flatulence, pruritus, rash, eczema. Rare: raised liver enzymes. Frequency unknown: urine discoloration (chromaturia). Melanosis coli has been reported rarely.International label, same formulation · Base de Données Publique des Médicaments (ANSM, France)

• Hypersensitivity to diacerein, rhein or any excipient.International label, same formulation · Base de Données Publique des Médicaments (ANSM, France)
• Inflammatory bowel disease (ulcerative colitis, Crohn's disease), occlusive or sub-occlusive syndromes, and abdominal pain of unknown cause.International label, same formulation · Base de Données Publique des Médicaments (ANSM, France)
• Current or past liver disease.International label, same formulation · Base de Données Publique des Médicaments (ANSM, France)

• Diarrhoea is frequent and may lead to dehydration and hypokalaemia; stop treatment if diarrhoea occurs. Avoid laxatives.International label, same formulation · Base de Données Publique des Médicaments (ANSM, France)
• Hepatotoxicity: raised liver enzymes and acute liver injury have been reported (mostly in the first months); check for liver disease before starting, monitor for signs of liver injury, stop if liver enzymes rise, and limit alcohol.International label, same formulation · Base de Données Publique des Médicaments (ANSM, France)
• Contains lactose; not suitable for patients with rare hereditary galactose intolerance, total lactase deficiency or glucose-galactose malabsorption.International label, same formulation · Base de Données Publique des Médicaments (ANSM, France)

• Gastrointestinal antacids and adsorbents (aluminium, calcium or magnesium salts, oxides, hydroxides)Reduce diacerein absorption; take them more than 2 hours apart.Base de Données Publique des Médicaments (ANSM, France)
• Diuretics and cardiac glycosides (e.g. digoxin)Diarrhoea-related hypokalaemia increases the risk of arrhythmia/glycoside toxicity; use with caution.Base de Données Publique des Médicaments (ANSM, France)
• LaxativesShould be avoided because of additive diarrhoea.Base de Données Publique des Médicaments (ANSM, France)

• Not recommended during pregnancy: clinical data are insufficient; animal studies showed delayed ossification at maternotoxic doses.International label, same formulation · Base de Données Publique des Médicaments (ANSM, France)
• Not recommended during breastfeeding; small amounts of anthraquinone derivatives pass into breast milk.International label, same formulation · Base de Données Publique des Médicaments (ANSM, France)

• Diacerein: Anthraquinone derivative with moderate anti-inflammatory activity, fully metabolised to rhein; inhibits interleukin-1 in vitro; its effect appears slowly (from about day 30, significant by day 45).