سعر بارافون 18 كبسولة 250 مجم / 300 مجم 2022

Parafon capsules containing chlorzoxazone 250 mg + paracetamol 300 mg, pack of 18 capsules (3 strips x 6), Mina Pharm under licence from Janssen-Cilag (Egypt).

• Adjunct to rest, physical therapy and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions (chlorzoxazone component).DailyMed (U.S. National Library of Medicine)

• Chlorzoxazone: drowsiness, dizziness, light-headedness, malaise or overstimulation occasionally; rarely GI bleeding, allergic skin rashes, petechiae or ecchymoses; angioneurotic oedema or anaphylaxis extremely rare; harmless urine discoloration.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Chlorzoxazone: known intolerance to the drug.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Paracetamol: hypersensitivity; concomitant use of other paracetamol-containing medicines.General active-ingredient information · electronic medicines compendium (emc)

• Chlorzoxazone: rare serious (including fatal) idiosyncratic hepatocellular toxicity; stop immediately if fever, rash, anorexia, nausea, vomiting, fatigue, right upper quadrant pain, dark urine, jaundice or abnormal liver enzymes occur. Additive effect with alcohol or other CNS depressants.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Paracetamol: do not exceed the stated dose (risk of delayed serious liver damage); care in severe renal or hepatic impairment; HAGMA due to pyroglutamic acidosis reported with risk factors or flucloxacillin.General active-ingredient information · electronic medicines compendium (emc)

• Alcohol / CNS depressantsAdditive effect with chlorzoxazone.DailyMed (U.S. National Library of Medicine)
• Warfarin and other coumarinsChronic paracetamol use may enhance anticoagulant effect.electronic medicines compendium (emc)

• Chlorzoxazone: safe use in pregnancy has not been established; use in women of childbearing potential only when benefits outweigh risks.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Paracetamol: large amount of data indicate no malformative or feto/neonatal toxicity; use lowest effective dose for shortest time if needed.General active-ingredient information · electronic medicines compendium (emc)

• Chlorzoxazone: Acts primarily at the spinal cord and subcortical brain areas, inhibiting multisynaptic reflex arcs involved in skeletal muscle spasm (US label); mode of action not clearly identified and may relate to sedative properties.
• Paracetamol (acetaminophen): Analgesic and antipyretic; the precise mechanism is not fully established and is thought to involve mainly central inhibition of prostaglandin synthesis and an action on the hypothalamic heat-regulating centre.