سعر ميولدين 4مجم 20 قرص 2022

Myoldin 4 mg tablets (Sigma, Egypt): tizanidine, a centrally acting alpha-2 adrenergic agonist skeletal muscle relaxant; pack of 20 tablets (2 strips).

• Treatment of spasticity in adults.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most common adverse reactions (>10% and more than placebo): dry mouth, somnolence, asthenia and dizziness.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Concomitant use with strong CYP1A2 inhibitors (e.g. fluvoxamine, ciprofloxacin).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• History of hypersensitivity to tizanidine or the product ingredients (anaphylaxis and angioedema have been reported).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypotension: monitor, particularly with concurrent antihypertensives; do not use with other alpha-2 adrenergic agonists.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Risk of liver injury: monitor aminotransferases and discontinue if liver injury occurs.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Sedation may interfere with everyday activities; effects of alcohol and other CNS depressants are additive. Hallucinations may occur (consider discontinuation).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Moderate or weak CYP1A2 inhibitors (e.g. zileuton, amiodarone, mexiletine, propafenone, verapamil, cimetidine, famotidine, acyclovir, ticlopidine)Avoid concomitant use; if necessary and hypotension, bradycardia or excessive drowsiness occur, reduce the dose or stop tizanidine.DailyMed (U.S. National Library of Medicine)
• Oral contraceptivesConcomitant use is not recommended (reduced tizanidine clearance).DailyMed (U.S. National Library of Medicine)
• Alcohol and other CNS depressantsAdditive sedative effects.DailyMed (U.S. National Library of Medicine)

• There are no adequate data on developmental risk in pregnant women; in animal studies tizanidine caused developmental toxicity (embryofetal and postnatal mortality, growth deficits) at doses below clinical doses.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• No data on presence in human milk or effects on the breastfed infant; tizanidine is present in animal milk. Weigh benefits of breastfeeding against maternal need.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Tizanidine: Central alpha-2 adrenergic agonist that presumably reduces spasticity by increasing presynaptic inhibition of motor neurons (US label).