سعر ببتيك كير 250مجم 28 قرص 2023

Peptic Care lower-strength (clarithromycin 250 mg) H. pylori triple-therapy combination pack (clarithromycin + omeprazole + tinidazole), enteric-coated tablets.

• Omeprazole: hypersensitivity to substituted benzimidazoles; co-administration with rilpivirine.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Clarithromycin: hypersensitivity to macrolides; co-administration with pimozide, cisapride, ergot alkaloids, lovastatin, simvastatin, lomitapide or lurasidone; colchicine in renal or hepatic impairment; history of QT prolongation or cholestatic jaundice with clarithromycin.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Tinidazole: hypersensitivity to nitroimidazoles; first trimester of pregnancy; breastfeeding during therapy and for 72 hours after the last dose.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Clarithromycin: QT prolongation, hepatotoxicity, Clostridioides difficile-associated diarrhoea, exacerbation of myasthenia gravis.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Tinidazole: boxed warning on carcinogenicity seen with metronidazole in animals (avoid unnecessary use); seizures/peripheral neuropathy; avoid alcohol during and for 3 days after therapy.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Omeprazole: PPI class warnings (gastric malignancy masking, C. difficile diarrhoea, fractures, hypomagnesaemia, vitamin B12 deficiency, tubulointerstitial nephritis).General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Strong CYP3A substrates (e.g. simvastatin, lovastatin, pimozide, ergot alkaloids, colchicine)Clarithromycin is a strong CYP3A inhibitor; contraindicated or dose-limited combinations.DailyMed (U.S. National Library of Medicine)
• AlcoholTinidazole: abdominal cramps, nausea, vomiting, headache and flushing may occur; avoid alcohol during and for 3 days after therapy.DailyMed (U.S. National Library of Medicine)
• ClopidogrelOmeprazole reduces the antiplatelet activity of clopidogrel; avoid concomitant use.DailyMed (U.S. National Library of Medicine)

• Tinidazole is contraindicated in the first trimester; clarithromycin is not recommended in pregnancy unless no alternative therapy is appropriate.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Tinidazole: interrupt breastfeeding during therapy and for 72 hours after the last dose.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Clarithromycin: Binds the 50S ribosomal subunit and inhibits bacterial protein synthesis.
• Omeprazole: Suppresses gastric acid secretion by specific inhibition of the H+/K+ ATPase (proton pump) at the secretory surface of the gastric parietal cell (US Zegerid label).
• Tinidazole: