سعر هيليكيور 250/20/500 مجم أقراص 2024

Helicobacter pylori triple-therapy pack (Egyphar) containing clarithromycin 250 mg, omeprazole 20 mg and tinidazole 500 mg; 14 enteric coated tablets.

• Treatment of Helicobacter pylori infection (triple therapy).

• Most common adverse reactions with a single 2 g dose of tinidazole (incidence >1%): metallic/bitter taste, nausea, weakness/fatigue/malaise, dyspepsia/cramps/epigastric discomfort, vomiting, anorexia, headache, dizziness and constipation.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Tinidazole is contraindicated in patients with a previous history of hypersensitivity to tinidazole or other nitroimidazole derivatives (reactions from urticaria to Stevens-Johnson syndrome) and in patients with Cockayne syndrome.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Clarithromycin is contraindicated with hypersensitivity to clarithromycin or any macrolide; with cisapride or pimozide; with a history of cholestatic jaundice/hepatic dysfunction on clarithromycin; with colchicine in renal or hepatic impairment; with lomitapide, lovastatin or simvastatin; with ergot alkaloids (ergotamine, dihydroergotamine); and with lurasidone.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Omeprazole is contraindicated in patients with known hypersensitivity (including anaphylaxis) to the formulation or any substituted benzimidazole, and in patients receiving rilpivirine-containing products.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Boxed warning (tinidazole): carcinogenicity has been seen in mice and rats treated chronically with metronidazole, a structurally related nitroimidazole; use should be reserved for approved indications.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Tinidazole: seizures and peripheral neuropathy have been reported; discontinue if abnormal neurologic signs develop.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Clarithromycin: avoid in patients with known QT prolongation, ventricular arrhythmia (torsades de pointes), uncorrected hypokalaemia/hypomagnesaemia, significant bradycardia, or those taking QT-prolonging drugs or class IA/III antiarrhythmics.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• AlcoholAvoid alcoholic beverages and alcohol-containing preparations during tinidazole therapy and for 3 days afterwards.DailyMed (U.S. National Library of Medicine)
• Lithium; cyclosporine; tacrolimus; fluorouracilTinidazole: monitor serum lithium concentrations, and monitor for cyclosporine, tacrolimus or fluorouracil toxicity when co-administered.DailyMed (U.S. National Library of Medicine)
• RilpivirineProton pump inhibitors including omeprazole are contraindicated with rilpivirine-containing products.DailyMed (U.S. National Library of Medicine)

• Based on animal findings, clarithromycin is not recommended for use in pregnant women except in clinical circumstances where no alternative therapy is appropriate.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Tinidazole is excreted in breast milk at concentrations similar to serum and can be detected for up to 72 hours; interruption of breastfeeding is recommended during therapy and for 3 days after the last dose.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

English text not available for this section.