سعر برادكسا 110مجم 30 كبسولة 2022

Pradaxa

معلومات الدواء

دواعي الاستعمالUses

Reduce risk of stroke and systemic embolism in adults with non-valvular atrial fibrillationDailyMed (US NLM)
Treatment of DVT and PE in adults after 5-10 days of parenteral anticoagulation; reduction of risk of recurrence of DVT and PEDailyMed (US NLM)
Prophylaxis of DVT and PE after hip replacement surgery in adultsDailyMed (US NLM)

Reduce risk of stroke and systemic embolism in adults with non-valvular atrial fibrillationDailyMed (US NLM)
Treatment of DVT and PE in adults after 5-10 days of parenteral anticoagulation; reduction of risk of recurrence of DVT and PEDailyMed (US NLM)
Prophylaxis of DVT and PE after hip replacement surgery in adultsDailyMed (US NLM)

الآثار الجانبيةSide effects

Most common (>15%): gastrointestinal adverse reactions and bleeding.نشرة دولية لنفس التركيبة · DailyMed (US NLM)

Most common (>15%): gastrointestinal adverse reactions and bleeding.International label, same formulation · DailyMed (US NLM)

موانع الاستعمالContraindications

Active pathological bleeding.نشرة دولية لنفس التركيبة · DailyMed (US NLM)
History of serious hypersensitivity reaction to dabigatran or excipients.نشرة دولية لنفس التركيبة · DailyMed (US NLM)
Mechanical prosthetic heart valve.نشرة دولية لنفس التركيبة · DailyMed (US NLM)

Active pathological bleeding.International label, same formulation · DailyMed (US NLM)
History of serious hypersensitivity reaction to dabigatran or excipients.International label, same formulation · DailyMed (US NLM)
Mechanical prosthetic heart valve.International label, same formulation · DailyMed (US NLM)

تحذيرات واحتياطاتWarnings & precautions

Boxed warning: premature discontinuation increases the risk of thrombotic events; spinal/epidural haematoma with neuraxial anaesthesia or spinal puncture.نشرة دولية لنفس التركيبة · DailyMed (US NLM)
Can cause serious and fatal bleeding; risk increased with antiplatelets, heparin, fibrinolytics, chronic NSAIDs and renal impairment.نشرة دولية لنفس التركيبة · DailyMed (US NLM)
Not recommended in bioprosthetic heart valves or triple-positive antiphospholipid syndrome.نشرة دولية لنفس التركيبة · DailyMed (US NLM)

Boxed warning: premature discontinuation increases the risk of thrombotic events; spinal/epidural haematoma with neuraxial anaesthesia or spinal puncture.International label, same formulation · DailyMed (US NLM)
Can cause serious and fatal bleeding; risk increased with antiplatelets, heparin, fibrinolytics, chronic NSAIDs and renal impairment.International label, same formulation · DailyMed (US NLM)
Not recommended in bioprosthetic heart valves or triple-positive antiphospholipid syndrome.International label, same formulation · DailyMed (US NLM)

التداخلات الدوائيةDrug interactions

P-gp inducers (e.g. rifampin)Reduce dabigatran exposure; generally avoid coadministration.DailyMed (US NLM)
P-gp inhibitors (e.g. dronedarone, systemic ketoconazole)Increase exposure, especially with renal impairment; dose reduction or avoidance depending on CrCl and indication.DailyMed (US NLM)

P-gp inducers (e.g. rifampin)Reduce dabigatran exposure; generally avoid coadministration.DailyMed (US NLM)
P-gp inhibitors (e.g. dronedarone, systemic ketoconazole)Increase exposure, especially with renal impairment; dose reduction or avoidance depending on CrCl and indication.DailyMed (US NLM)

الحمل والرضاعةPregnancy & breastfeeding

Limited human data are insufficient to determine drug-associated developmental risk; anticoagulants may increase bleeding risk in the fetus and neonate.نشرة دولية لنفس التركيبة · DailyMed (US NLM)
Breastfeeding is not recommended during treatment.نشرة دولية لنفس التركيبة · DailyMed (US NLM)

Limited human data are insufficient to determine drug-associated developmental risk; anticoagulants may increase bleeding risk in the fetus and neonate.International label, same formulation · DailyMed (US NLM)
Breastfeeding is not recommended during treatment.International label, same formulation · DailyMed (US NLM)

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