سعر اوكانداب 75مجم 10 كبسول 2022

Okandab: dabigatran etexilate 75 mg capsules, pack of 10 (Mash Premiere, Egypt); oral direct thrombin inhibitor anticoagulant.

• Reduce risk of stroke and systemic embolism in adult NVAF (US Pradaxa label).Population: Adults with NVAFDailyMed / FDA
• Treatment of DVT/PE after parenteral anticoagulation; reduction of recurrence; hip-replacement VTE prophylaxis (US label).Population: AdultsDailyMed / FDA

• Active pathological bleeding; history of serious hypersensitivity to dabigatran; mechanical prosthetic heart valve (US Pradaxa).International label, equivalent formulation · DailyMed / FDA

• Boxed warning: premature discontinuation increases thrombotic events; spinal/epidural hematoma risk with neuraxial procedures. Can cause serious or fatal bleeding.International label, equivalent formulation · DailyMed / FDA
• Not recommended with bioprosthetic heart valves; increased thrombosis risk in triple-positive antiphospholipid syndrome.International label, equivalent formulation · DailyMed / FDA

• P-gp inducers (e.g., rifampin)MajorAvoid coadministration; reduces dabigatran exposure (US label).DailyMed / FDA
• P-gp inhibitors (e.g., ketoconazole, dronedarone) especially with renal impairmentMajorMay increase dabigatran levels; dose adjustments/avoidance per US label and renal function.DailyMed / FDA
• Other anticoagulants / antiplatelets / NSAIDsMajorAdditive bleeding risk (US label).DailyMed / FDA

• US label (PLLR): limited data; use only if potential benefit justifies potential risk. May increase bleeding risk.International label, equivalent formulation · DailyMed / FDA

• Dabigatran etexilate: Oral prodrug converted to dabigatran, a competitive direct thrombin inhibitor that prevents thrombus development.