دواعي استعمال بريفاجليب 5مجم 30 قرص

Linagliptin 5 mg film-coated tablets (DPP-4 inhibitor) for type 2 diabetes, box of 30 tablets, by Eva Pharma, Egypt.

• Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus (not for type 1 diabetes)الفئة: AdultsDailyMed (U.S. National Library of Medicine)

• Most common adverse reaction (>=5% and more than placebo): nasopharyngitis.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to linagliptin or any excipient (anaphylaxis, angioedema, exfoliative skin conditions, urticaria or bronchial hyperreactivity reported).نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Acute pancreatitis, including fatal cases, has been reported; discontinue if suspected.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Hypoglycemia risk with insulin or insulin secretagogues; consider lowering their dose.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Serious hypersensitivity reactions, severe and disabling arthralgia, bullous pemphigoid and heart failure are described in the US label.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Strong P-gp or CYP3A4 inducers (e.g. rifampin)Reduced linagliptin exposure and possibly efficacy; alternative treatment strongly recommended.DailyMed (U.S. National Library of Medicine)

• Limited human data are insufficient to inform drug-associated risk; poorly controlled diabetes in pregnancy carries maternal and fetal risks; no adverse developmental effects in rats at clinically relevant exposures.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• No human milk data; linagliptin is present in rat milk; weigh benefits of breastfeeding against the clinical need.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• ليناغليبتين: يثبط DPP-4 فيرفع مستويات الإنكرتينات ويزيد إفراز الإنسولين المعتمد على الجلوكوز.مثبط لإنزيم ثنائي ببتيديل ببتيداز-4