سعر بيرال 250 مجم 5 اقماع 2025

Paracetamol 250 mg suppository (5 suppositories) by Kahira Pharmaceuticals and Chemical Industries, Egypt.

• Very rare: thrombocytopenia, agranulocytosis, anaphylaxis, skin hypersensitivity reactions including serious skin reactions, bronchospasm (mainly in aspirin/NSAID-sensitive asthmatics), hepatic dysfunction; HAGMA frequency not known.General active-ingredient information · electronic medicines compendium (emc)

• Hypersensitivity to paracetamol or any other ingredient; do not combine with other paracetamol-containing medicines.General active-ingredient information · electronic medicines compendium (emc)

• Do not exceed the stated dose: overdose can cause delayed, serious liver damage; seek medical help at once after overdose even if well.General active-ingredient information · electronic medicines compendium (emc)
• Use with care in severe renal or hepatic impairment; overdose hazards are greater in non-cirrhotic alcoholic liver disease.General active-ingredient information · electronic medicines compendium (emc)
• High anion gap metabolic acidosis due to pyroglutamic acidosis has been reported with prolonged therapeutic use in severe illness, malnutrition or glutathione deficiency, or with flucloxacillin.General active-ingredient information · electronic medicines compendium (emc)

• Warfarin and other coumarinsChronic paracetamol use may enhance the anticoagulant effect with increased bleeding risk; occasional doses have no significant effect.electronic medicines compendium (emc)
• ColestyramineReduces paracetamol absorption; do not take within one hour if maximal analgesia is required.electronic medicines compendium (emc)
• Metoclopramide, domperidoneAccelerate paracetamol absorption; concurrent use need not be avoided.electronic medicines compendium (emc)
• FlucloxacillinConcurrent use associated with high anion gap metabolic acidosis, especially with risk factors.electronic medicines compendium (emc)
• AlcoholReduces liver capacity to handle paracetamol.electronic medicines compendium (emc)

• Large amounts of data indicate neither malformative nor feto/neonatal toxicity; neurodevelopment data are inconclusive. If clinically needed, use the lowest effective dose for the shortest time at the lowest frequency.General active-ingredient information · electronic medicines compendium (emc)
• Excreted in breast milk but not in clinically significant quantities; published data do not contraindicate breastfeeding.General active-ingredient information · electronic medicines compendium (emc)

• Paracetamol: Probably acts mainly by inhibiting prostaglandin synthesis in the CNS; antipyretic action on the hypothalamic heat-regulating centre (UK SmPC).