دواعي استعمال رادروزا 0.03/3مجم 21 قرص

Combined oral contraceptive: ethinyl estradiol 0.03 mg + drospirenone 3 mg film-coated tablets, pack of 21 (Magic Pharma / Marcyrl, Egypt).

• Prevention of pregnancy in females of reproductive potential.الفئة: Females of reproductive potentialDailyMed (U.S. National Library of Medicine)

• Most common (>=2%): premenstrual syndrome, headache/migraine, breast pain/tenderness, nausea/vomiting, abdominal pain and mood changes.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Renal impairment; adrenal insufficiency.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• High risk of arterial or venous thrombotic disease, e.g. smokers over 35, current or past DVT/PE, cerebrovascular or coronary artery disease, thrombogenic valvular/rhythm heart disease, inherited or acquired hypercoagulopathies, uncontrolled hypertension, diabetes with vascular disease.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Use with hepatitis C regimens containing ombitasvir/paritaprevir/ritonavir, with or without dasabuvir.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Boxed warning: cigarette smoking increases the risk of serious cardiovascular events from COC use, especially over age 35; women over 35 who smoke should not use COCs.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Drospirenone-containing COCs may carry a higher VTE risk than levonorgestrel COCs; stop if an arterial or venous thrombotic event occurs.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Hyperkalaemia risk (drospirenone 3 mg is comparable to spironolactone 25 mg); check serum potassium in the first cycle in women on long-term potassium-raising drugs (ACE inhibitors, ARBs, potassium-sparing diuretics, NSAIDs, heparin, potassium supplements).نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Discontinue if jaundice develops; monitor blood pressure, glucose tolerance in prediabetic/diabetic women, new or worsening headache or migraine, and depression.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• CYP3A4 inducers (e.g. phenytoin, carbamazepine, barbiturates, rifampin, St John's wort, topiramate, bosentan)May decrease contraceptive effectiveness or increase breakthrough bleeding; use back-up or alternative contraception.DailyMed (U.S. National Library of Medicine)

• No use for contraception in pregnancy; discontinue if pregnancy occurs. Studies have not found an increased risk of birth defects after exposure before conception or in early pregnancy.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Drospirenone is present in human milk (about 0.1% of the maternal dose); combined hormonal contraceptives can reduce milk production.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Yearly visit for blood pressure check and other indicated care; serum potassium in the first cycle for at-risk patients.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)