دواعي استعمال ريلاترولين 25مجم 20 كبسولة

Dantrolene 25 mg capsules, a peripherally (directly) acting skeletal muscle relaxant that interferes with calcium release from the sarcoplasmic reticulum.

• Control of clinical spasticity from upper motor neuron disorders (e.g. spinal cord injury, stroke, cerebral palsy, multiple sclerosis); not indicated for skeletal muscle spasm from rheumatic disorders.الفئة: Adults and childrenDailyMed (NLM)
• Pre-operative prevention/attenuation of malignant hyperthermia in susceptible patients and post-crisis follow-up.DailyMed (NLM)

• Most frequent: drowsiness, dizziness, weakness, general malaise, fatigue and diarrhoea (may be severe); others include hepatitis, seizures, visual disturbance, tachycardia, pleural effusion with eosinophilia, and urinary disturbances.نشرة دولية لنفس التركيبة · DailyMed (NLM)

• Active hepatic disease such as hepatitis and cirrhosis; where spasticity is used to sustain upright posture and balance or to obtain/maintain function.نشرة دولية لنفس التركيبة · DailyMed (NLM)

• Boxed warning: potential for hepatotoxicity, including fatal and non-fatal symptomatic hepatitis; risk higher with doses of 800 mg/day or more, in females, patients over 35 years and those on other medicines.نشرة دولية لنفس التركيبة · DailyMed (NLM)
• Use with caution in impaired pulmonary function (especially obstructive disease), severely impaired cardiac function and history of liver disease; may cause drowsiness (avoid driving) and possible photosensitivity.نشرة دولية لنفس التركيبة · DailyMed (NLM)

• CNS depressants (sedatives, tranquilizers)Additive drowsiness.DailyMed (NLM)
• EstrogensHepatotoxicity occurred more often in women over 35 on concomitant estrogen; use caution.DailyMed (NLM)
• Calcium channel blockers (e.g. verapamil)Combination not recommended during management of malignant hyperthermia (cardiovascular collapse/hyperkalaemia reported).DailyMed (NLM)
• VecuroniumDantrolene may potentiate vecuronium-induced neuromuscular block.DailyMed (NLM)

• Adequate animal reproduction studies not conducted; give to a pregnant woman only if clearly needed. Dantrolene crosses the placenta.نشرة دولية لنفس التركيبة · DailyMed (NLM)
• Should not be used in nursing mothers.نشرة دولية لنفس التركيبة · DailyMed (NLM)

• Baseline liver function tests (SGOT, SGPT, alkaline phosphatase, total bilirubin) and periodic liver function monitoring during therapy; discontinue if abnormal.نشرة دولية لنفس التركيبة · DailyMed (NLM)

• Dissociates skeletal muscle excitation-contraction coupling, probably by interfering with Ca++ release from the sarcoplasmic reticulum.