دواعي استعمال ريتاديل 250مجم 20 كبسول

Penicillamine 250 mg capsules, 20 per pack (Delta Pharma); chelating agent used for Wilson's disease, cystinuria and severe rheumatoid arthritis.

• Wilson's disease.DailyMed (U.S. National Library of Medicine)
• Cystinuria.DailyMed (U.S. National Library of Medicine)
• Severe, active rheumatoid arthritis in patients who failed an adequate trial of conventional therapy.DailyMed (U.S. National Library of Medicine)

• Allergic: pruritus, early and late rashes (5%), pemphigus, drug eruptions, lupus-like syndrome.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Gastrointestinal: anorexia, epigastric pain, nausea, vomiting or diarrhea (17%); taste blunting or loss (12%); oral ulcerations.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Hematological: bone marrow depression, leukopenia (2%), thrombocytopenia (4%); fatal agranulocytosis and aplastic anemia reported.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Renal: proteinuria (6%) and/or hematuria, possibly progressing to nephrotic syndrome; renal failure reported.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Pregnancy, except for treatment of Wilson's disease or certain patients with cystinuria.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Nursing mothers should not breastfeed during therapy.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• History of penicillamine-related aplastic anemia or agranulocytosis.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Rheumatoid arthritis patients with a history or other evidence of renal insufficiency.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Fatalities have been associated with aplastic anemia, agranulocytosis, thrombocytopenia, Goodpasture's syndrome and myasthenia gravis.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Drug fever, sometimes with rash, may occur in the second to third week of therapy.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Penicillamine increases pyridoxine requirement; patients may need a daily pyridoxine supplement.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Food, antacids and ironReduce penicillamine absorption; separate administration by at least 1 hour from other drugs, food or milk.DailyMed (U.S. National Library of Medicine)

• Penicillamine can cause fetal harm; congenital cutis laxa and associated birth defects have been reported after in-utero exposure.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
• Mothers on penicillamine therapy should not nurse their infants.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Urinalysis, white and differential blood count, hemoglobin and direct platelet count twice weekly during the first month, every two weeks for the next 5 months, then monthly; also monitor skin, lymph nodes and body temperature.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

• Chelates copper for urinary excretion in Wilson's disease and forms soluble penicillamine-cysteine disulfide, reducing cystine excretion in cystinuria (US label).