دواعي استعمال ريبوبي 10مجم فيال وريد.عضل 5 مل

معلومات من نشرات دوائية ومراجع موثقة، مع مصدر كل معلومة. السعر الحالي: 60ج.م.

دواعي الاستعمال

Component of adjuvant therapy in patients with axillary node tumour involvement following resection of primary breast cancer.DailyMed (U.S. National Library of Medicine)

الآثار الجانبية

Most common (10% or more): leukopenia, neutropenia, anaemia, thrombocytopenia, amenorrhoea, lethargy, nausea/vomiting, mucositis, diarrhoea, infection, conjunctivitis/keratitis, alopecia, local skin toxicity and rash/itch.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

موانع الاستعمال

Severe myocardial insufficiency.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
Recent myocardial infarction or severe arrhythmias, or previous treatment with maximum cumulative dose of anthracyclines.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
Severe persistent drug-induced myelosuppression.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
Severe hepatic impairment (Child-Pugh C or serum bilirubin above 5 mg/dL).نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
Severe hypersensitivity to epirubicin, other anthracyclines or anthracenediones.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

تحذيرات واحتياطات

Boxed warning - cardiac toxicity: myocardial damage including acute left ventricular failure; cardiomyopathy risk rises with cumulative dose (0.9% at 550 mg/m2, 1.6% at 700 mg/m2, 3.3% at 900 mg/m2).نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
Boxed warning - secondary AML and myelodysplastic syndrome occur at higher incidence with anthracyclines.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
Boxed warning - extravasation can cause severe local tissue injury and necrosis; stop the infusion immediately and apply ice.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
Boxed warning - severe myelosuppression resulting in serious infection, septic shock, transfusion, hospitalisation and death may occur.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
Other warnings: tumour lysis syndrome, immunosuppression/infection risk, thrombophlebitis and thromboembolic events, potentiation of radiation toxicity and radiation recall, embryo-fetal toxicity.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

التداخلات الدوائية

Cardiotoxic agents (e.g. trastuzumab, calcium channel blockers)Increased risk of cardiotoxicity; monitor cardiac function closely and delay epirubicin after long half-life cardiotoxic agents such as trastuzumab.DailyMed (U.S. National Library of Medicine)
CimetidineCimetidine increases epirubicin exposure; discontinue cimetidine during treatment.DailyMed (U.S. National Library of Medicine)

الحمل والرضاعة

Can cause fetal harm based on animal data and mechanism; avoid use during the first trimester; rare reports of fetal/neonatal cardiotoxicity after 2nd/3rd trimester exposure.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
Advise not to breastfeed during treatment and for at least 7 days after the last dose.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

المتابعة أثناء العلاج

Assess left ventricular ejection fraction before, regularly during and after treatment.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

كيف يعمل الدواء

Anthracycline topoisomerase inhibitor (US Ellence label: DNA intercalation, topoisomerase II inhibition).

المصادر