دواعي استعمال ريمكتازيد 300مجم 8 اقراص

Rimactazide coated tablets (isoniazid + rifampicin, labelled 300 mg; pack of 8) by Novartis, an Egyptian fixed-dose antituberculosis combination.

• Treatment of all forms of tuberculosis, including fresh, advanced and chronic cases.electronic medicines compendium (emc)

• Rifampicin: pyrexia, chills (very common); thrombocytopenia, headache, dizziness, nausea, vomiting, raised bilirubin and transaminases, paradoxical reaction (common).نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc)
• Isoniazid: severe and sometimes fatal hepatitis, convulsions, toxic encephalopathy, optic neuritis (uncommon); peripheral neuropathy especially in slow acetylators.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc)

• Hypersensitivity to rifamycins, isoniazid or any excipient.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc)
• Jaundice.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc)
• Concurrent saquinavir/ritonavir.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc)
• Medicines strongly affected by enzyme induction: lurasidone, sofosbuvir, daclatasvir, telaprevir, cabotegravir, fostemsavir, lenacapavir.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc)

• Both components are associated with liver dysfunction: baseline liver tests for all patients, monthly review, and monthly transaminases in patients over 35 years; severe and sometimes fatal isoniazid hepatitis may occur even after months.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc)
• Severe cutaneous adverse reactions (SJS, TEN, AGEP), DRESS and thrombotic microangiopathy (TTP/HUS) have been reported; withdraw immediately if suspected.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc)
• Rifampicin may cause vitamin K dependent coagulopathy and interstitial lung disease; discolours body fluids and may stain soft contact lenses.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc)
• Monitor isoniazid use in slow acetylators, epilepsy, psychosis, peripheral neuropathy, diabetes, alcohol dependence, HIV or porphyria; elderly or malnourished patients may need vitamin B6.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc)
• Contains sucrose and sunset yellow (E110) in the UK product.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc)

• Hormonal contraceptivesRifampicin reduces systemic exposure; use non-hormonal contraception.electronic medicines compendium (emc)
• AntacidsReduce absorption of rifampicin and isoniazid; give rifampicin at least 1 hour before antacids.electronic medicines compendium (emc)
• Tyramine/histamine-rich foodsIsoniazid inhibits MAO and DAO; may cause headache, sweating, palpitations, flushing and hypotension.electronic medicines compendium (emc)
• ParacetamolMay increase the risk of hepatotoxicity with rifampicin.electronic medicines compendium (emc)

• Use in pregnancy only if the potential benefit justifies the potential risk to the fetus; rifampicin is teratogenic in rodents at large doses.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc)
• Both drugs pass into breast milk; avoid breast-feeding unless benefit outweighs risk; theoretical risk of convulsions and neuropathy in the infant, consider pyridoxine for mother and infant.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc)

• Baseline hepatic enzymes, bilirubin, serum creatinine, complete blood count and platelets; at least monthly review; monthly transaminases in patients over 35.نشرة دولية لتركيبة مكافئة · electronic medicines compendium (emc)

• Inhibits bacterial DNA-dependent RNA polymerase.
• Bactericidal; inhibits mycolic acid synthesis needed for the mycobacterial cell wall.