سعر ريمكتازيد 300مجم 8 اقراص 2022

Rimactazide coated tablets (isoniazid + rifampicin, labelled 300 mg; pack of 8) by Novartis, an Egyptian fixed-dose antituberculosis combination.

• Treatment of all forms of tuberculosis, including fresh, advanced and chronic cases.electronic medicines compendium (emc)

• Rifampicin: pyrexia, chills (very common); thrombocytopenia, headache, dizziness, nausea, vomiting, raised bilirubin and transaminases, paradoxical reaction (common).International label, equivalent formulation · electronic medicines compendium (emc)
• Isoniazid: severe and sometimes fatal hepatitis, convulsions, toxic encephalopathy, optic neuritis (uncommon); peripheral neuropathy especially in slow acetylators.International label, equivalent formulation · electronic medicines compendium (emc)

• Hypersensitivity to rifamycins, isoniazid or any excipient.International label, equivalent formulation · electronic medicines compendium (emc)
• Jaundice.International label, equivalent formulation · electronic medicines compendium (emc)
• Concurrent saquinavir/ritonavir.International label, equivalent formulation · electronic medicines compendium (emc)

• Both components are associated with liver dysfunction: baseline liver tests for all patients, monthly review, and monthly transaminases in patients over 35 years; severe and sometimes fatal isoniazid hepatitis may occur even after months.International label, equivalent formulation · electronic medicines compendium (emc)
• Severe cutaneous adverse reactions (SJS, TEN, AGEP), DRESS and thrombotic microangiopathy (TTP/HUS) have been reported; withdraw immediately if suspected.International label, equivalent formulation · electronic medicines compendium (emc)
• Rifampicin may cause vitamin K dependent coagulopathy and interstitial lung disease; discolours body fluids and may stain soft contact lenses.International label, equivalent formulation · electronic medicines compendium (emc)

• Hormonal contraceptivesRifampicin reduces systemic exposure; use non-hormonal contraception.electronic medicines compendium (emc)
• AntacidsReduce absorption of rifampicin and isoniazid; give rifampicin at least 1 hour before antacids.electronic medicines compendium (emc)
• Tyramine/histamine-rich foodsIsoniazid inhibits MAO and DAO; may cause headache, sweating, palpitations, flushing and hypotension.electronic medicines compendium (emc)

• Use in pregnancy only if the potential benefit justifies the potential risk to the fetus; rifampicin is teratogenic in rodents at large doses.International label, equivalent formulation · electronic medicines compendium (emc)
• Both drugs pass into breast milk; avoid breast-feeding unless benefit outweighs risk; theoretical risk of convulsions and neuropathy in the infant, consider pyridoxine for mother and infant.International label, equivalent formulation · electronic medicines compendium (emc)

• Rifampicin: Inhibits bacterial DNA-dependent RNA polymerase.
• Isoniazid: Bactericidal; inhibits mycolic acid synthesis needed for the mycobacterial cell wall.