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دواعي استعمال ريفوتريل 0.5مجم 50 اقراص

معلومات من نشرات دوائية ومراجع موثقة، مع مصدر كل معلومة. السعر الحالي: 15.6ج.م.

دواعي الاستعمال
  • Seizure disorders: alone or as adjunctive treatment of Lennox-Gastaut syndrome (petit mal variant), akinetic and myoclonic seizures; may be useful in absence seizures (petit mal) that have failed to respond to succinimides.DailyMed (U.S. National Library of Medicine)
  • Panic disorder, with or without agoraphobia, as defined in DSM-5.الفئة: AdultsDailyMed (U.S. National Library of Medicine)
الآثار الجانبية
  • Seizure disorders: most frequent adverse reactions are drowsiness (about 50%), ataxia (about 30%) and behaviour problems (about 25%).نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Panic disorder trials: somnolence (37%), depression, coordination abnormal, ataxia, dizziness, fatigue and memory disturbance.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
موانع الاستعمال
  • History of sensitivity to benzodiazepines.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Clinical or biochemical evidence of significant liver disease.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Acute narrow-angle glaucoma (may be used in open-angle glaucoma receiving appropriate therapy).نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
تحذيرات واحتياطات
  • Boxed warning: concomitant use with opioids may result in profound sedation, respiratory depression, coma and death; reserve concomitant prescribing for patients without alternatives and limit dose and duration.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Boxed warning: use exposes users to risks of abuse, misuse and addiction, which can lead to overdose or death; assess each patient's risk before prescribing and throughout treatment.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Boxed warning: continued use may lead to clinically significant physical dependence; abrupt discontinuation or rapid dose reduction may precipitate acute withdrawal reactions, which can be life-threatening; use a gradual taper.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Antiepileptic drugs increase the risk of suicidal thoughts or behaviour; monitor for emergence or worsening of depression and unusual changes in mood or behaviour.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • May impair mental and physical abilities; caution patients about operating hazardous machinery and driving; may increase seizure frequency of generalised tonic-clonic seizures in mixed seizure disorders.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Periodic blood counts and liver function tests are advisable during long-term therapy; may cause hypersalivation, caution in patients with compromised respiratory function.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
التداخلات الدوائية
  • OpioidsIncreased risk of profound sedation, respiratory depression, coma and death (boxed warning).DailyMed (U.S. National Library of Medicine)
  • CNS depressants and alcoholAdditive CNS-depressant effects (other antiepileptics, sedatives, antidepressants, antipsychotics, alcohol).DailyMed (U.S. National Library of Medicine)
  • CYP450 inducers (phenytoin, carbamazepine, lamotrigine, phenobarbital)Increase clonazepam clearance, decreasing plasma concentrations by approximately 38% (phenobarbital 19-24%).DailyMed (U.S. National Library of Medicine)
  • CYP3A inhibitors (e.g. oral antifungals)Use with caution; clonazepam is metabolised by CYP3A.DailyMed (U.S. National Library of Medicine)
الحمل والرضاعة
  • Neonatal sedation and withdrawal syndrome: use late in pregnancy can result in sedation (respiratory depression, lethargy, hypotonia) and/or withdrawal symptoms in the neonate; monitor neonates exposed in utero.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Clonazepam is excreted in human milk; monitor breastfed infants for sedation and poor feeding, and consider the benefits of breastfeeding alongside the mother's clinical need.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
كيف يعمل الدواء
  • Benzodiazepine; precise mechanism not fully understood, believed to be related to enhancement of GABA activity in the CNS (Klonopin USPI section 12.1).
سعر ريفوتريل 0.5مجم 50 اقراصالمثائل والبدائل

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