سعر ريفوتريل 2.5مجم/مل نقط للفم 10 مل 2024
Rivotril 2.5 mg/ml oral dropsمعلومات الدواء
الآثار الجانبيةSide effects
- Seizure disorders: most frequent adverse reactions are drowsiness (about 50%), ataxia (about 30%) and behaviour problems (about 25%).معلومة عامة عن المادة الفعالة · DailyMed (U.S. National Library of Medicine)
- Panic disorder trials: somnolence (37%), depression, coordination abnormal, ataxia, dizziness, fatigue and memory disturbance.معلومة عامة عن المادة الفعالة · DailyMed (U.S. National Library of Medicine)
- Seizure disorders: most frequent adverse reactions are drowsiness (about 50%), ataxia (about 30%) and behaviour problems (about 25%).General active-ingredient information · DailyMed (U.S. National Library of Medicine)
- Panic disorder trials: somnolence (37%), depression, coordination abnormal, ataxia, dizziness, fatigue and memory disturbance.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
موانع الاستعمالContraindications
- History of sensitivity to benzodiazepines.معلومة عامة عن المادة الفعالة · DailyMed (U.S. National Library of Medicine)
- Clinical or biochemical evidence of significant liver disease.معلومة عامة عن المادة الفعالة · DailyMed (U.S. National Library of Medicine)
- Acute narrow-angle glaucoma (may be used in open-angle glaucoma receiving appropriate therapy).معلومة عامة عن المادة الفعالة · DailyMed (U.S. National Library of Medicine)
- History of sensitivity to benzodiazepines.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
- Clinical or biochemical evidence of significant liver disease.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
- Acute narrow-angle glaucoma (may be used in open-angle glaucoma receiving appropriate therapy).General active-ingredient information · DailyMed (U.S. National Library of Medicine)
تحذيرات واحتياطاتWarnings & precautions
- Boxed warning: concomitant use with opioids may result in profound sedation, respiratory depression, coma and death; reserve concomitant prescribing for patients without alternatives and limit dose and duration.معلومة عامة عن المادة الفعالة · DailyMed (U.S. National Library of Medicine)
- Boxed warning: use exposes users to risks of abuse, misuse and addiction, which can lead to overdose or death; assess each patient's risk before prescribing and throughout treatment.معلومة عامة عن المادة الفعالة · DailyMed (U.S. National Library of Medicine)
- Boxed warning: continued use may lead to clinically significant physical dependence; abrupt discontinuation or rapid dose reduction may precipitate acute withdrawal reactions, which can be life-threatening; use a gradual taper.معلومة عامة عن المادة الفعالة · DailyMed (U.S. National Library of Medicine)
- Antiepileptic drugs increase the risk of suicidal thoughts or behaviour; monitor for emergence or worsening of depression and unusual changes in mood or behaviour.معلومة عامة عن المادة الفعالة · DailyMed (U.S. National Library of Medicine)
- May impair mental and physical abilities; caution patients about operating hazardous machinery and driving; may increase seizure frequency of generalised tonic-clonic seizures in mixed seizure disorders.معلومة عامة عن المادة الفعالة · DailyMed (U.S. National Library of Medicine)
- Periodic blood counts and liver function tests are advisable during long-term therapy; may cause hypersalivation, caution in patients with compromised respiratory function.معلومة عامة عن المادة الفعالة · DailyMed (U.S. National Library of Medicine)
- Boxed warning: concomitant use with opioids may result in profound sedation, respiratory depression, coma and death; reserve concomitant prescribing for patients without alternatives and limit dose and duration.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
- Boxed warning: use exposes users to risks of abuse, misuse and addiction, which can lead to overdose or death; assess each patient's risk before prescribing and throughout treatment.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
- Boxed warning: continued use may lead to clinically significant physical dependence; abrupt discontinuation or rapid dose reduction may precipitate acute withdrawal reactions, which can be life-threatening; use a gradual taper.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
- Antiepileptic drugs increase the risk of suicidal thoughts or behaviour; monitor for emergence or worsening of depression and unusual changes in mood or behaviour.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
- May impair mental and physical abilities; caution patients about operating hazardous machinery and driving; may increase seizure frequency of generalised tonic-clonic seizures in mixed seizure disorders.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
- Periodic blood counts and liver function tests are advisable during long-term therapy; may cause hypersalivation, caution in patients with compromised respiratory function.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
التداخلات الدوائيةDrug interactions
- OpioidsIncreased risk of profound sedation, respiratory depression, coma and death (boxed warning).DailyMed (U.S. National Library of Medicine)
- CNS depressants and alcoholAdditive CNS-depressant effects (other antiepileptics, sedatives, antidepressants, antipsychotics, alcohol).DailyMed (U.S. National Library of Medicine)
- CYP450 inducers (phenytoin, carbamazepine, lamotrigine, phenobarbital)Increase clonazepam clearance, decreasing plasma concentrations by approximately 38% (phenobarbital 19-24%).DailyMed (U.S. National Library of Medicine)
- CYP3A inhibitors (e.g. oral antifungals)Use with caution; clonazepam is metabolised by CYP3A.DailyMed (U.S. National Library of Medicine)
- OpioidsIncreased risk of profound sedation, respiratory depression, coma and death (boxed warning).DailyMed (U.S. National Library of Medicine)
- CNS depressants and alcoholAdditive CNS-depressant effects (other antiepileptics, sedatives, antidepressants, antipsychotics, alcohol).DailyMed (U.S. National Library of Medicine)
- CYP450 inducers (phenytoin, carbamazepine, lamotrigine, phenobarbital)Increase clonazepam clearance, decreasing plasma concentrations by approximately 38% (phenobarbital 19-24%).DailyMed (U.S. National Library of Medicine)
- CYP3A inhibitors (e.g. oral antifungals)Use with caution; clonazepam is metabolised by CYP3A.DailyMed (U.S. National Library of Medicine)
الحمل والرضاعةPregnancy & breastfeeding
- Neonatal sedation and withdrawal syndrome: use late in pregnancy can result in sedation (respiratory depression, lethargy, hypotonia) and/or withdrawal symptoms in the neonate; monitor neonates exposed in utero.معلومة عامة عن المادة الفعالة · DailyMed (U.S. National Library of Medicine)
- Clonazepam is excreted in human milk; monitor breastfed infants for sedation and poor feeding, and consider the benefits of breastfeeding alongside the mother's clinical need.معلومة عامة عن المادة الفعالة · DailyMed (U.S. National Library of Medicine)
- Neonatal sedation and withdrawal syndrome: use late in pregnancy can result in sedation (respiratory depression, lethargy, hypotonia) and/or withdrawal symptoms in the neonate; monitor neonates exposed in utero.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
- Clonazepam is excreted in human milk; monitor breastfed infants for sedation and poor feeding, and consider the benefits of breastfeeding alongside the mother's clinical need.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
كيف يعمل الدواءHow it works
- Benzodiazepine; precise mechanism not fully understood, believed to be related to enhancement of GABA activity in the CNS (Klonopin USPI section 12.1).
- Clonazepam: Benzodiazepine; precise mechanism not fully understood, believed to be related to enhancement of GABA activity in the CNS (Klonopin USPI section 12.1).
تاريخ السعر
تغيّر السعر الرسمي: من 30 إلى 87 ج.م، 2 أسعار مسجلة
| التاريخ | السعر (ج.م) |
|---|---|
| سعر سابق بدون تاريخ | 30 |
| 87 |
| التاريخ | من | إلى | التغيير |
|---|---|---|---|
| 30ج.م | 87ج.م | زيادة 190% |
المعرّفات
- الباركود
- 7640128013730
أدوية ذات صلة
نفس المادة الفعالة بتركيز آخر
منتجات أخرى من F. Hoffmann-La Roche (distributor: Egyptian Pharmaceutical Trading Company)
من فئة مضاد للصرع
المصادر
- السعر: قوائم أسعار الأدوية المنشورة في مصر.
- DailyMed (U.S. National Library of Medicine)
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