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دواعي استعمال رونيكارد 200مجم 30 قرص

معلومات من نشرات دوائية ومراجع موثقة، مع مصدر كل معلومة. السعر الحالي: 7.5ج.م.

دواعي الاستعمال
  • Life-threatening recurrent ventricular fibrillation and recurrent haemodynamically unstable ventricular tachycardia not responding to other antiarrhythmicsالفئة: AdultsDailyMed (U.S. National Library of Medicine)
الآثار الجانبية
  • Serious adverse reactions include pulmonary toxicity, hepatic injury, worsened arrhythmia, visual impairment and loss of vision, thyroid abnormalities, bradycardia, peripheral neuropathy, photosensitivity and skin discoloration.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
موانع الاستعمال
  • Cardiogenic shock.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Sick sinus syndrome, second- or third-degree AV block, or bradycardia leading to syncope without a functioning pacemaker.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Known hypersensitivity to the drug or any of its components, including iodine.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
تحذيرات واحتياطات
  • Boxed warning: pulmonary toxicity (hypersensitivity or interstitial/alveolar pneumonitis) at rates up to 17% in some series, fatal about 10% of the time; hepatic injury and worsened arrhythmia also possible. For use only in life-threatening arrhythmias.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
التداخلات الدوائية
  • WarfarinPotentiates anticoagulant response with possible serious or fatal bleeding; reduce warfarin dose by one-third to one-half and monitor prothrombin time.DailyMed (U.S. National Library of Medicine)
  • Digoxin, beta blockers, verapamil, diltiazem, clonidine, ivabradineNegative chronotropes potentiate effects of amiodarone, causing bradycardia, sinus arrest and AV block; monitor heart rate.DailyMed (U.S. National Library of Medicine)
  • CYP450 inhibitors (grapefruit juice, certain fluoroquinolones and macrolides, azole antifungals, cimetidine, certain protease inhibitors)Increased amiodarone exposure; avoid concomitant use.DailyMed (U.S. National Library of Medicine)
  • Simvastatin, lovastatinIncreased statin concentration; limit simvastatin to 20 mg and lovastatin to 40 mg.DailyMed (U.S. National Library of Medicine)
الحمل والرضاعة
  • Use in pregnancy may increase the risk of fetal adverse effects including neonatal hypo- and hyperthyroidism, neonatal bradycardia, neurodevelopmental abnormalities, preterm birth and fetal growth restriction; amiodarone and desethylamiodarone cross the placenta.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Amiodarone and desethylamiodarone are present in breast milk; breastfeeding is not recommended during treatment.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
المتابعة أثناء العلاج
  • Obtain baseline chest X-ray, pulmonary function tests, thyroid function tests and liver aminotransferases; correct hypokalaemia, hypomagnesaemia and hypocalcaemia before starting.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
  • Repeat history, physical examination and chest X-ray every 3 to 6 months (pulmonary toxicity).نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
كيف يعمل الدواء
  • Class III antiarrhythmic with electrophysiologic characteristics of all four Vaughan Williams classes; lengthens the cardiac action potential, blocks sodium and myocardial potassium channels and has noncompetitive antisympathetic action (US label section 12.1).
سعر رونيكارد 200مجم 30 قرصالمثائل والبدائل

المصادر