سعر رونيزيروكس 500مجم 10 اقراص 2022

Ronisirox 500 mg

معلومات الدواء

دواعي الاستعمالUses

Chronic iron overload due to blood transfusions (transfusional haemosiderosis)الفئة: Patients 2 years of age and olderDailyMed (U.S. National Library of Medicine)
Chronic iron overload in non-transfusion-dependent thalassaemia syndromes (LIC at least 5 mg Fe/g dry weight and serum ferritin above 300 mcg/L)الفئة: Patients 10 years of age and olderDailyMed (U.S. National Library of Medicine)

Chronic iron overload due to blood transfusions (transfusional haemosiderosis)Population: Patients 2 years of age and olderDailyMed (U.S. National Library of Medicine)
Chronic iron overload in non-transfusion-dependent thalassaemia syndromes (LIC at least 5 mg Fe/g dry weight and serum ferritin above 300 mcg/L)Population: Patients 10 years of age and olderDailyMed (U.S. National Library of Medicine)

الآثار الجانبيةSide effects

Transfusional iron overload: most frequent (more than 5%) adverse reactions are diarrhoea, vomiting, nausea, abdominal pain, skin rashes and increases in serum creatinine.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
NTDT syndromes: most frequent (more than 5%) adverse reactions are diarrhoea, rash and nausea.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

Transfusional iron overload: most frequent (more than 5%) adverse reactions are diarrhoea, vomiting, nausea, abdominal pain, skin rashes and increases in serum creatinine.International label, same formulation · DailyMed (U.S. National Library of Medicine)
NTDT syndromes: most frequent (more than 5%) adverse reactions are diarrhoea, rash and nausea.International label, same formulation · DailyMed (U.S. National Library of Medicine)

موانع الاستعمالContraindications

Estimated GFR less than 40 mL/min/1.73 m2.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
Poor performance status.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
High-risk myelodysplastic syndromes.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

Estimated GFR less than 40 mL/min/1.73 m2.International label, same formulation · DailyMed (U.S. National Library of Medicine)
Poor performance status.International label, same formulation · DailyMed (U.S. National Library of Medicine)
High-risk myelodysplastic syndromes.International label, same formulation · DailyMed (U.S. National Library of Medicine)

تحذيرات واحتياطاتWarnings & precautions

Boxed warning: may cause acute renal failure and death, hepatic failure and gastrointestinal haemorrhage, particularly in patients with comorbidities or advanced haematologic disorders.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

Boxed warning: may cause acute renal failure and death, hepatic failure and gastrointestinal haemorrhage, particularly in patients with comorbidities or advanced haematologic disorders.International label, same formulation · DailyMed (U.S. National Library of Medicine)

التداخلات الدوائيةDrug interactions

Hormonal contraceptivesDeferasirox can render hormonal contraceptives ineffective; use non-hormonal contraception.DailyMed (U.S. National Library of Medicine)
Aluminium-containing antacidsDo not take deferasirox with aluminium-containing antacid products.DailyMed (U.S. National Library of Medicine)

Hormonal contraceptivesDeferasirox can render hormonal contraceptives ineffective; use non-hormonal contraception.DailyMed (U.S. National Library of Medicine)
Aluminium-containing antacidsDo not take deferasirox with aluminium-containing antacid products.DailyMed (U.S. National Library of Medicine)

الحمل والرضاعةPregnancy & breastfeeding

No studies in pregnant women; animal data showed decreased offspring viability and renal anomalies in rats. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)
No human data on presence in milk; deferasirox is excreted in rat milk. Decide whether to discontinue breastfeeding or the drug, considering the importance of the drug to the mother.نشرة دولية لنفس التركيبة · DailyMed (U.S. National Library of Medicine)

No studies in pregnant women; animal data showed decreased offspring viability and renal anomalies in rats. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus.International label, same formulation · DailyMed (U.S. National Library of Medicine)
No human data on presence in milk; deferasirox is excreted in rat milk. Decide whether to discontinue breastfeeding or the drug, considering the importance of the drug to the mother.International label, same formulation · DailyMed (U.S. National Library of Medicine)

كيف يعمل الدواءHow it works

Orally active chelator selective for iron (Fe3+); a tridentate ligand binding iron with high affinity in a 2:1 ratio (US label 12.1).

Deferasirox: Orally active chelator selective for iron (Fe3+); a tridentate ligand binding iron with high affinity in a 2:1 ratio (US label 12.1).

نفس المادة الفعالة والتركيز. اسأل الصيدلي قبل الاستبدال.

مثائل رونيزيروكس 500مجم 10 اقراص بنفس المادة الفعالة والتركيز، مرتبة من الأرخص
الدواء	السعر	الفرق عن الأصلي
اندوراسيروكس 500مجم 20قرصAndorasirox 500 mg 20 tablets for oral suspensionAl Andalous Pharmaceutical Industries · أقراص للمعلق الفموي (أقراص قابلة للتشتت) · 500 mgالأرخص	السعر1,530ج.م76.5ج.م للوحدة	الفرق عن الأصليأغلى 705ج.م (85.5%)
اكسجيد 500 مجم 28 قرصExjadeNovartis · أقراص قابلة للتشتت (لتحضير معلق فموي) · 500 mg per tablet	السعر4,950ج.م176.79ج.م للوحدة	الفرق عن الأصليأغلى 4,125ج.م (500%)
ديفيروكسينوفا 500 مجم 10 أقراصDeferoxinova 500mg 10 disp. tabs.Innova Pharma · أقراص قابلة للتفريق · 500 mgشكل مختلف	السعر765ج.م76.5ج.م للوحدة	الفرق عن الأصليأرخص 60ج.م (7.3%)
رازيروكسبين 500مجم 28 اقراصRasiroxpineHikma Specialized Pharmaceuticals · 500 mgشكل مختلف	السعر2,142ج.م76.5ج.م للوحدة	الفرق عن الأصليأغلى 1,317ج.م (159.6%)

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