سعر افيروبيوس 642.9مجم/5مل 75 مل معلق 2024

Amoxicillin 600 mg + clavulanic acid 42.9 mg per 5 ml powder for oral suspension (Averobios 642.9 mg/5 ml, 14:1 extra-strength paediatric formulation), 75 ml bottle, marketed by Averroes Pharma (Egypt); manufactured by Sigmatec.

• Recurrent or persistent acute otitis media due to S. pneumoniae (penicillin MIC 2 mcg/mL or less), H. influenzae or M. catarrhalis (including beta-lactamase-producing strains) in children with risk factors (antibacterial exposure for otitis media within the preceding 3 months and either age 2 years or younger or day-care attendance). Not indicated when S. pneumoniae penicillin MIC is 4 mcg/mL or more.Population: Children 3 months to 12 years weighing 40 kg or lessDailyMed (U.S. National Library of Medicine)
• Acute bacterial sinusitis in children 3 months to 12 years (paediatric-use section of the label, supported by adult AUGMENTIN XR studies and pharmacokinetic bridging).Population: Children 3 months to 12 yearsDailyMed (U.S. National Library of Medicine)

• Most frequent adverse reactions (incidence above 4%) in paediatric acute otitis media trials (90/6.4 mg/kg/day for 10 days): coughing, vomiting, contact dermatitis (diaper rash), fever, upper respiratory tract infection and diarrhoea; in the comparative trial coughing 12%, vomiting 7%, diaper rash 6%, fever 6%, protocol-defined diarrhoea 11%.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Postmarketing (amoxicillin/clavulanate products): tooth discoloration (mostly in children), interstitial nephritis, haematuria and crystalluria, blood dyscrasias (anaemia, thrombocytopenia, eosinophilia, leukopenia, agranulocytosis) and CNS effects (agitation, anxiety, convulsions, dizziness, insomnia, reversible hyperactivity).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• History of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to amoxicillin, clavulanate or other beta-lactam antibacterials (penicillins, cephalosporins).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• History of cholestatic jaundice/hepatic dysfunction associated with amoxicillin/clavulanate.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Serious and occasionally fatal hypersensitivity (anaphylactic) reactions; severe cutaneous adverse reactions (SJS, TEN, DRESS, AGEP); drug-induced enterocolitis syndrome; hepatic dysfunction and cholestatic jaundice; Clostridioides difficile-associated diarrhoea; erythematous rash in patients with mononucleosis (avoid use); superinfection with fungi or bacteria.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• The US product contains aspartame: 7 mg phenylalanine per 5 mL (relevant for phenylketonurics); the Egyptian excipients were not verified.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• ProbenecidDecreases renal tubular secretion of amoxicillin, increasing and prolonging amoxicillin blood levels; co-administration is not recommended.DailyMed (U.S. National Library of Medicine)
• Oral anticoagulantsAbnormal prolongation of prothrombin time (increased INR) reported; monitor and adjust the anticoagulant dose if needed.DailyMed (U.S. National Library of Medicine)
• AllopurinolConcurrent use increases the incidence of rash.DailyMed (U.S. National Library of Medicine)

• Published epidemiologic studies and pharmacovigilance reports over several decades have not established a drug-associated risk of major birth defects, miscarriage or adverse maternal outcomes with amoxicillin and clavulanate in pregnancy.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Amoxicillin is present in human milk; diarrhoea, irritability and rash have been reported in exposed breastfed infants, who should be monitored for these symptoms.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Amoxicillin: Bactericidal beta-lactam that inhibits bacterial cell-wall synthesis; inactivated by beta-lactamases.
• Clavulanic acid: Beta-lactam that inactivates some beta-lactamases, protecting amoxicillin from degradation.