سعر روكسيسين 300مجم 5 اقراص 2022

Roxithromycin 300 mg film-coated tablets, pack of 5 (Roxicin, El-Obour, Egypt); macrolide antibiotic.

• Upper respiratory tract infections: acute pharyngitis, tonsillitis, sinusitisPopulation: Adults (mild to moderately severe infections)sanofi-aventis australia pty ltd (hosted copy, e-lactancia.org)
• Lower respiratory tract infections: acute bronchitis, acute exacerbations of chronic bronchitis, community-acquired pneumoniaPopulation: Adults (mild to moderately severe infections)sanofi-aventis australia pty ltd (hosted copy, e-lactancia.org)
• Skin and skin structure infectionsPopulation: Adults (mild to moderately severe infections)sanofi-aventis australia pty ltd (hosted copy, e-lactancia.org)

• Gastrointestinal: nausea, vomiting, epigastric pain, diarrhoea (sometimes bloody), anorexia, flatulence.International label, same formulation · sanofi-aventis australia pty ltd (hosted copy, e-lactancia.org)
• Hypersensitivity: urticaria, rash, pruritus, angioedema; rarely anaphylaxis, bronchospasm, erythema multiforme, Stevens-Johnson syndrome.International label, same formulation · sanofi-aventis australia pty ltd (hosted copy, e-lactancia.org)
• Liver: moderate rises in transaminases/alkaline phosphatase; rarely acute cholestatic or hepatocellular hepatitis.International label, same formulation · sanofi-aventis australia pty ltd (hosted copy, e-lactancia.org)

• Known hypersensitivity to macrolides, including erythromycin.International label, same formulation · sanofi-aventis australia pty ltd (hosted copy, e-lactancia.org)
• Severely impaired hepatic function.International label, same formulation · sanofi-aventis australia pty ltd (hosted copy, e-lactancia.org)
• Concomitant vasoconstrictive ergot alkaloids (e.g. ergotamine, dihydroergotamine).International label, same formulation · sanofi-aventis australia pty ltd (hosted copy, e-lactancia.org)

• Gastrointestinal adverse events were more frequent with the 300 mg once-daily regimen than with 150 mg twice daily.International label, same formulation · sanofi-aventis australia pty ltd (hosted copy, e-lactancia.org)
• May prolong the QT interval: use with caution in congenital QT prolongation, uncorrected hypokalaemia/hypomagnesaemia, significant bradycardia, or with class IA/III antiarrhythmics.International label, same formulation · sanofi-aventis australia pty ltd (hosted copy, e-lactancia.org)
• Antibiotic-associated diarrhoea/pseudomembranous colitis and superinfection with resistant organisms may occur.International label, same formulation · sanofi-aventis australia pty ltd (hosted copy, e-lactancia.org)

• Ergot alkaloids (ergotamine, dihydroergotamine)Ergotism with possible peripheral necrosis reported with macrolides; combination contraindicated.sanofi-aventis australia pty ltd (hosted copy, e-lactancia.org)
• Warfarin and other vitamin K antagonistsIncreased INR/prothrombin time reported; monitor INR.sanofi-aventis australia pty ltd (hosted copy, e-lactancia.org)
• Digoxin and other cardiac glycosidesRoxithromycin may increase digoxin absorption; monitor ECG and, if possible, digoxin levels.sanofi-aventis australia pty ltd (hosted copy, e-lactancia.org)

• Australian category B1: animal studies at the stated doses showed no developmental abnormalities (embryotoxicity in rats above 180 mg/kg/day); safety for the human fetus not established.International label, same formulation · sanofi-aventis australia pty ltd (hosted copy, e-lactancia.org)
• Small amounts are excreted in breast milk; discontinue breastfeeding or treatment as necessary.International label, same formulation · sanofi-aventis australia pty ltd (hosted copy, e-lactancia.org)

• Roxithromycin: Semi-synthetic macrolide that binds the 50S ribosomal subunit and inhibits bacterial protein synthesis.