سعر سايزن 6 مجم/1.03 مل 2025

Recombinant human growth hormone (somatropin) 6 mg in 1.03 ml solution for injection in a cartridge (5.83 mg/ml), for subcutaneous use with the easypod auto-injector or aluetta pen injector.

• Growth failure in children due to decreased or absent endogenous growth hormone secretion.Population: Children and adolescentselectronic medicines compendium (emc), UK
• Growth failure in girls with gonadal dysgenesis (Turner syndrome) confirmed by chromosomal analysis.Population: Girls with Turner syndromeelectronic medicines compendium (emc), UK
• Growth failure in prepubertal children due to chronic renal failure.Population: Prepubertal children with chronic renal failureelectronic medicines compendium (emc), UK

• Injection-site redness and itching (up to 10% of patients).International label, same product · electronic medicines compendium (emc), UK
• Fluid retention in adults (oedema, joint swelling, arthralgia, myalgia, paraesthesia), usually transient and dose-dependent.International label, same product · electronic medicines compendium (emc), UK
• Antibodies to somatropin in a small percentage of patients, of low binding capacity.International label, same product · electronic medicines compendium (emc), UK

• Hypersensitivity to somatropin or any excipient.International label, same product · electronic medicines compendium (emc), UK
• Growth promotion in children with closed epiphyses.International label, same product · electronic medicines compendium (emc), UK
• Any evidence of active tumour; intracranial tumours must be inactive and antitumour therapy completed before starting.International label, same product · electronic medicines compendium (emc), UK

• Somatropin may reduce insulin sensitivity: monitor for glucose intolerance; insulin doses in diabetics may need adjustment.International label, same product · electronic medicines compendium (emc), UK
• May unmask hypothyroidism (increased T4 to T3 conversion) and central hypoadrenalism; monitor thyroid function and adjust glucocorticoid replacement.International label, same product · electronic medicines compendium (emc), UK
• Benign intracranial hypertension: perform funduscopy if severe or recurrent headache, visual problems, nausea or vomiting occur; discontinue if confirmed.International label, same product · electronic medicines compendium (emc), UK

• GlucocorticoidsGlucocorticoids inhibit the growth-promoting effect; GH decreases cortisone-to-cortisol conversion and may unmask central hypoadrenalism or make low replacement doses ineffective.electronic medicines compendium (emc), UK
• Oral oestrogen replacementWomen on oral oestrogen may need a higher somatropin dose.electronic medicines compendium (emc), UK
• CYP3A4 substrates (e.g. sex steroids, corticosteroids, anticonvulsants, ciclosporin)Somatropin may increase clearance of CYP450 (especially CYP3A4) substrates, lowering their plasma levels; clinical significance unknown.electronic medicines compendium (emc), UK

• No clinical data on exposed pregnancies; animal studies show no increased embryo-fetal risk, but somatropin is not recommended during pregnancy or in women of childbearing potential not using contraception.International label, same product · electronic medicines compendium (emc), UK
• Not known whether somatropin is excreted in human milk; use with caution in breast-feeding women.International label, same product · electronic medicines compendium (emc), UK

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