سعر سانديميون نيورال 50مجم 50 كبسولة 2026

Ciclosporin 50 mg soft gelatin capsules (Sandimmun Neoral, Novartis); pack of 50 capsules.

• Prophylaxis of organ rejection in kidney, liver and heart allogeneic transplants.DailyMed (U.S. National Library of Medicine)
• Severe active rheumatoid arthritis not adequately responding to methotrexate (alone or combined with methotrexate).Population: AdultsDailyMed (U.S. National Library of Medicine)
• Severe, recalcitrant plaque psoriasis in non-immunocompromised adults who failed or cannot use other systemic therapy.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Principal adverse reactions in transplantation: renal dysfunction, tremor, hirsutism, hypertension and gum hyperplasia; hypertension occurs in about 50% of renal and most cardiac transplant patients. Hypomagnesaemia and glomerular capillary thrombosis reported.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to cyclosporine or any ingredient. RA and psoriasis patients with abnormal renal function, uncontrolled hypertension or malignancies. Psoriasis patients receiving concomitant PUVA/UVB, methotrexate or other immunosuppressants, coal tar or radiation.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: to be prescribed only by physicians experienced in systemic immunosuppression; increased susceptibility to infection and neoplasia (lymphoma); Neoral and Sandimmune are not bioequivalent; can cause hypertension and nephrotoxicity; psoriasis patients previously treated with PUVA have increased skin-malignancy risk.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Nephrotoxicity and hepatotoxicity increase with dose; monitor serum creatinine frequently; elderly patients need particular care. The alcohol content of Neoral should be considered in pregnancy, breastfeeding, liver disease, epilepsy and children.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Nephrotoxic drugs (e.g. aminoglycosides, amphotericin B, NSAIDs, tacrolimus, trimethoprim-sulfamethoxazole)May potentiate renal dysfunction; closely monitor serum creatinine.DailyMed (U.S. National Library of Medicine)
• CYP3A4 / P-glycoprotein inhibitors and inducersCyclosporine is extensively metabolised by CYP3A; inhibitors raise and inducers lower cyclosporine concentrations, requiring monitoring and dose adjustment.DailyMed (U.S. National Library of Medicine)
• Diclofenac, methotrexateCoadministration in RA patients significantly increased diclofenac and methotrexate AUC.DailyMed (U.S. National Library of Medicine)

• Decades of published data have not identified a drug-associated risk of major birth defects or miscarriage; hypertension, pre-eclampsia, preterm birth and low birth weight are increased in treated patients (confounded by underlying disease). A pregnancy registry (TPRI) exists.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Cyclosporine is excreted in human milk; the alcohol content of Neoral should be considered in breastfeeding women.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Ciclosporin: Binds cyclophilin; the complex inhibits calcineurin phosphatase, blocking IL-2 transcription and T-lymphocyte activation and proliferation.