سعر سيزوكالم 50مجم 10 كبسول 2022

Seizocalm 50 mg capsules, pack of 10, by Al Esraa Pharmaceutical Optima (Egypt); zonisamide antiepileptic (sulfonamide).

• Adjunctive therapy of partial seizuresPopulation: Adults (over 16 years)DailyMed (U.S. National Library of Medicine)

• Most common (incidence at least 4% greater than placebo): somnolence, anorexia, dizziness, ataxia, agitation/irritability and difficulty with memory and/or concentration.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to sulfonamides or zonisamide.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Potentially fatal reactions to sulfonamides, serious skin reactions, serious haematological events (aplastic anaemia, agranulocytosis) and DRESS/multi-organ hypersensitivity have been reported; consider discontinuation for unexplained rash.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hyperchloraemic, non-anion-gap metabolic acidosis (can occur at doses as low as 25 mg daily) and kidney stones; increasing fluid intake may help reduce stone risk.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Oligohidrosis and hyperthermia (heat stroke), especially in children; acute myopia and secondary angle-closure glaucoma; suicidal behaviour and ideation; cognitive/neuropsychiatric effects including somnolence; hyperammonaemia and encephalopathy; seizures on abrupt withdrawal; teratogenicity (women of childbearing potential should use effective contraception).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Other carbonic anhydrase inhibitors (e.g. topiramate, acetazolamide, dichlorphenamide)May increase the severity of metabolic acidosis and the risks of kidney stones and hyperammonaemia; monitor for metabolic acidosis.DailyMed (U.S. National Library of Medicine)
• Alcohol and other CNS depressantsNot evaluated clinically; use with caution because of potential CNS depression and cognitive/neuropsychiatric effects.DailyMed (U.S. National Library of Medicine)

• Zonisamide may cause serious adverse fetal effects; it was teratogenic in several animal species, and metabolic acidosis in pregnancy may be associated with decreased fetal growth and oxygenation. Monitor pregnant patients for metabolic acidosis, and monitor newborns of treated mothers.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Zonisamide is excreted in human milk; decide whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother.International label, same formulation · DailyMed (U.S. National Library of Medicine)

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