سعر سبرينكازين 50 مجم 10 كبسولات 2022

Sprinkazen topiramate 50 mg sprinkle capsules, pack of 10, by Medizen Pharmaceutical Industries; antiepileptic.

• Epilepsy: monotherapy or adjunctive therapy of partial-onset, primary generalised tonic-clonic and Lennox-Gastaut seizuresPopulation: 2 years and olderDailyMed (U.S. National Library of Medicine)
• Preventive treatment of migrainePopulation: 12 years and olderDailyMed (U.S. National Library of Medicine)

• Epilepsy (most common): paraesthesia, anorexia, weight loss, speech problems, fatigue, dizziness, somnolence, nervousness, psychomotor slowing, abnormal vision, fever. Migraine: paraesthesia, anorexia, weight loss, memory difficulty, taste perversion, diarrhoea, hypoaesthesia, nausea, abdominal pain, upper respiratory infection.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• History of hypersensitivity to topiramate or any inactive ingredient (anaphylaxis and angioedema have occurred).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Acute myopia and secondary angle-closure glaucoma; visual field defects; oligohidrosis and hyperthermia (especially children); metabolic acidosis (measure bicarbonate); suicidal behaviour and ideation; cognitive/neuropsychiatric effects; fetal toxicity (oral clefts, small for gestational age); withdraw gradually; decreased bone mineral density and slowed growth in children; DRESS; hyperammonaemia/encephalopathy (with valproate); kidney stones.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Phenytoin, carbamazepineClinically significant decrease in topiramate plasma concentrations; dose adjustment may be needed.DailyMed (U.S. National Library of Medicine)
• Valproic acidAssociated with hypothermia and hyperammonaemia with or without encephalopathy.DailyMed (U.S. National Library of Medicine)
• Other carbonic anhydrase inhibitors (zonisamide, acetazolamide)May increase severity of metabolic acidosis and risk of kidney stones.DailyMed (U.S. National Library of Medicine)

• Can cause fetal harm: increased risk of major congenital malformations including oral clefts, and of small-for-gestational-age infants (dose-dependent). Women of childbearing potential not planning pregnancy should use effective contraception (efficacy of hormonal contraceptives may be reduced).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Excreted in human milk at levels similar to maternal plasma; diarrhoea and somnolence reported in breastfed infants.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Topiramate: Multiple mechanisms including voltage-gated sodium channel blockade, GABA-A potentiation, AMPA/kainate antagonism and carbonic anhydrase inhibition.