سعر سيجماستينال 20مجم/مل 1 امبول 2022

Sigmastinal 20 mg/ml is an Egyptian hyoscine butylbromide (hyoscine-N-butylbromide) solution for injection by Sigma Tec, supplied as 1 ampoule; it is an antimuscarinic antispasmodic.

• Acute spasm, as in renal or biliary colic.Population: Adultselectronic medicines compendium (emc), MHRA-authorised SmPC
• Radiology (differential diagnosis of obstruction; reduce spasm and pain in pyelography) and other diagnostic procedures where spasm may be a problem, e.g. gastro-duodenal endoscopy.Population: Adultselectronic medicines compendium (emc), MHRA-authorised SmPC

• Common: accommodation disorders, tachycardia, dizziness, dry mouth. Not known: anaphylactic shock (including fatal), anaphylactic reactions, dyspnoea, hypersensitivity, mydriasis, raised intraocular pressure, decreased blood pressure, flushing, skin reactions, abnormal sweating, urinary retention. Injection-site pain, particularly after intramuscular use.International label, same formulation · electronic medicines compendium (emc), MHRA-authorised SmPC

• Hypersensitivity to the active substance or excipients; narrow-angle glaucoma; prostatic hypertrophy with urinary retention; mechanical GI stenosis; paralytic or obstructive ileus; megacolon; tachycardia; myasthenia gravis.International label, same formulation · electronic medicines compendium (emc), MHRA-authorised SmPC
• Must not be given intramuscularly to patients on anticoagulants (risk of intramuscular haematoma).International label, same formulation · electronic medicines compendium (emc), MHRA-authorised SmPC

• Can cause tachycardia, hypotension and anaphylaxis (including shock, sometimes fatal); use with caution in cardiac failure, coronary heart disease, arrhythmia, hypertension and cardiac surgery; monitor patients and keep emergency equipment and trained staff available.International label, same formulation · electronic medicines compendium (emc), MHRA-authorised SmPC
• Investigate severe unexplained abdominal pain; caution in pyrexia (reduced sweating); may raise intraocular pressure in undiagnosed narrow-angle glaucoma (urgent eye review if painful red eye with visual loss).International label, same formulation · electronic medicines compendium (emc), MHRA-authorised SmPC
• Accommodation disorder or dizziness may occur; patients so affected should not drive or operate machinery.International label, same formulation · electronic medicines compendium (emc), MHRA-authorised SmPC

• Tri- and tetracyclic antidepressants, antihistamines, quinidine, amantadine, antipsychotics, disopyramide, other anticholinergics (e.g. tiotropium, ipratropium)Anticholinergic effect may be intensified.electronic medicines compendium (emc), MHRA-authorised SmPC
• Dopamine antagonists (e.g. metoclopramide)Diminished effects of both drugs on the gastrointestinal tract.electronic medicines compendium (emc), MHRA-authorised SmPC
• Beta-adrenergic agentsTachycardic effects may be enhanced.electronic medicines compendium (emc), MHRA-authorised SmPC

• There are limited data from use in pregnant women and animal studies are insufficient regarding reproductive toxicity; as a precaution, use during pregnancy is not recommended.International label, same formulation · electronic medicines compendium (emc), MHRA-authorised SmPC
• Insufficient information on excretion in human milk; a risk to the breastfed child cannot be excluded, and use during breastfeeding is not recommended.International label, same formulation · electronic medicines compendium (emc), MHRA-authorised SmPC

• Hyoscine butylbromide: Quaternary ammonium antispasmodic: peripheral anticholinergic action via ganglion blockade in the visceral wall and antimuscarinic activity on GI, biliary and genito-urinary smooth muscle; does not enter the CNS.