سعر سيلدينوفا 10مجم معلق شراب 120 مل 2022

Sildinova sildenafil powder for oral suspension, 120 ml bottle, labelled "10 mg" (International Drug Agency, IDI, Egypt).

• In the adult PAH study (SUPER-1) the most common adverse reactions more frequent than placebo included headache (46% at 20 mg three times daily), epistaxis, flushing, dyspepsia, insomnia, erythema, dyspnoea and rhinitis; reactions were generally transient and mild to moderate.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Contraindicated with concomitant organic nitrates in any form (regular or intermittent) because of the risk of hypotension, and with riociguat (guanylate cyclase stimulator).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Vasodilatory effects: consider carefully in patients on antihypertensives or with resting hypotension, fluid depletion, severe left ventricular outflow obstruction or autonomic dysfunction. Use in pulmonary veno-occlusive disease is not recommended. Epistaxis was more frequent in PAH secondary to connective tissue disease and with vitamin K antagonists.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Seek immediate medical attention for sudden loss of vision (NAION) or sudden decrease/loss of hearing; use in retinitis pigmentosa is not recommended. Prolonged erection over 4 hours requires immediate care. REVATIO may cause serious vaso-occlusive crises in pulmonary hypertension secondary to sickle cell disease.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• NitratesConcomitant use with nitrates in any form is contraindicated.DailyMed (U.S. National Library of Medicine)
• Strong CYP3A inhibitors (e.g. ritonavir)Concomitant use with strong CYP3A inhibitors is not recommended.DailyMed (U.S. National Library of Medicine)
• Moderate-to-strong CYP3A inducers (e.g. bosentan)Decrease sildenafil exposure; dose up-titration may be needed when starting them, and the dose should be reduced to 20 mg three times a day when they are stopped.DailyMed (U.S. National Library of Medicine)

• Limited published data (a case report) describe sildenafil and its active metabolite in human milk; information on effects on the breastfed infant and milk production is insufficient.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Sildenafil: Inhibits PDE5, the enzyme that degrades cGMP in the corpus cavernosum, enhancing the nitric oxide effect during sexual stimulation (smooth-muscle relaxation and inflow of blood).