سعر سورال 20مجم 20 كبسولة 2024

Tenoxicam 20 mg capsules, pack of 20 (2 strips); Global Napi Pharmaceuticals, Egypt.

• Mostly gastrointestinal: stomatitis (very common), abdominal pain, dyspepsia, nausea, peptic ulcer (common); dizziness and headache are common; oedema, rash, raised liver enzymes and raised urea/creatinine are uncommon.General active-ingredient information · Thai Food and Drug Administration (Thai FDA)

• Active or history of recurrent peptic ulcer/haemorrhage, history of GI bleeding or perforation related to previous NSAID therapy, or severe gastritis.General active-ingredient information · Thai Food and Drug Administration (Thai FDA)
• Hypersensitivity to tenoxicam or excipients, or previous asthma, rhinitis, angioedema or urticaria in response to aspirin or other NSAIDs.General active-ingredient information · Thai Food and Drug Administration (Thai FDA)
• Severe renal, hepatic or heart failure; last trimester of pregnancy.General active-ingredient information · Thai Food and Drug Administration (Thai FDA)

• Use the lowest effective dose for the shortest duration; GI bleeding, ulceration or perforation, which can be fatal, may occur at any time; risk is higher with higher doses, ulcer history and in the elderly; consider gastroprotection.General active-ingredient information · Thai Food and Drug Administration (Thai FDA)
• Possible small increased risk of arterial thrombotic events; fluid retention and oedema; caution in hypertension, heart failure and ischaemic, peripheral arterial or cerebrovascular disease.General active-ingredient information · Thai Food and Drug Administration (Thai FDA)
• Serious skin reactions (exfoliative dermatitis, Stevens-Johnson syndrome, TEN) very rarely; stop at first rash or mucosal lesion. Renal impairment, raised transaminases, inhibition of platelet aggregation, masking of infection and impaired female fertility may occur.General active-ingredient information · Thai Food and Drug Administration (Thai FDA)

• Other NSAIDs including aspirin and COX-2 inhibitorsAvoid: increased adverse effects; salicylates displace tenoxicam from protein binding.Thai Food and Drug Administration (Thai FDA)
• Anticoagulants (warfarin), anti-platelet agents, SSRIs, corticosteroidsIncreased risk of GI ulceration or bleeding; monitor anticoagulant effect closely.Thai Food and Drug Administration (Thai FDA)
• Lithium, methotrexateNSAIDs may reduce their elimination and increase toxicity; monitor.Thai Food and Drug Administration (Thai FDA)
• Diuretics and antihypertensives (beta-blockers, ACE inhibitors)Reduced antihypertensive/natriuretic effect and increased nephrotoxicity risk; tenoxicam attenuates the effect of hydrochlorothiazide.Thai Food and Drug Administration (Thai FDA)
• Ciclosporin, tacrolimusIncreased risk of nephrotoxicity.Thai Food and Drug Administration (Thai FDA)
• Quinolone antibioticsPossible increased risk of convulsions.Thai Food and Drug Administration (Thai FDA)

• Prostaglandin synthesis inhibition may adversely affect pregnancy (miscarriage, cardiac malformation, gastroschisis in early pregnancy); from week 20 may cause oligohydramnios and ductus arteriosus constriction; avoid in the first and second trimester unless clearly necessary.General active-ingredient information · Thai Food and Drug Administration (Thai FDA)
• A very small amount (mean under 0.3% of the dose) passes into breast milk; NSAIDs should be avoided if possible when breastfeeding.General active-ingredient information · Thai Food and Drug Administration (Thai FDA)

• In patients at risk monitor renal, hepatic and cardiac function (BUN, creatinine, oedema, weight); monitor elderly patients regularly for GI bleeding.General active-ingredient information · Thai Food and Drug Administration (Thai FDA)

• Tenoxicam: Inhibits cyclooxygenase and thereby peripheral prostaglandin synthesis, giving anti-inflammatory and analgesic effects.