سعر سبيروزايد 25/25مجم 20 قرص 2024

Spirozide tablets containing hydrochlorothiazide 25 mg and spironolactone 25 mg, 20 tablets per pack, by SEDICO (Egypt); a thiazide plus aldosterone-antagonist diuretic combination.

• Edema and sodium retention in congestive heart failure when partially responsive to or intolerant of other measures.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Cirrhosis of the liver with edema and/or ascites (maintenance therapy).Population: AdultsDailyMed (U.S. National Library of Medicine)
• Nephrotic syndrome when other treatments are inadequate.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Hydrochlorothiazide: weakness, orthostatic hypotension, pancreatitis, cholestatic jaundice, GI upset, acute myopia/angle-closure glaucoma, blood dyscrasias, hypersensitivity reactions. Spironolactone: GI disturbances, gynecomastia, sexual dysfunction, menstrual irregularities, electrolyte disturbances.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Anuria, acute renal insufficiency, significant impairment of renal excretory function, hypercalcemia, hyperkalemia, Addison's disease, and allergy to thiazides or other sulfonamide-derived drugs; may also be contraindicated in acute or severe hepatic failure.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Do not give potassium supplements or potassium-rich diet routinely; severe hyperkalemia may occur with other potassium-sparing diuretics, ACE inhibitors, ARBs, aldosterone blockers, NSAIDs, heparin/LMWH or potassium salt substitutes.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hydrochlorothiazide can cause acute angle-closure glaucoma and acute myopia/choroidal effusion; discontinue promptly if symptoms occur.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Thiazides may exacerbate systemic lupus erythematosus, alter glucose tolerance, raise lipids and uric acid, and raise serum calcium; non-melanoma skin cancer risk with hydrochlorothiazide (sun protection and skin screening advised).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• ACE inhibitors, ARBs, aldosterone blockers, potassium supplements, heparin/LMWHConcomitant use may lead to severe hyperkalemia.DailyMed (U.S. National Library of Medicine)
• LithiumDiuretics reduce lithium clearance; high risk of lithium toxicity; generally should not be co-administered.DailyMed (U.S. National Library of Medicine)
• NSAIDs (e.g., indomethacin)May reduce diuretic/antihypertensive effect; combination with potassium-sparing diuretics associated with severe hyperkalemia.DailyMed (U.S. National Library of Medicine)

• No adequate studies in pregnant women; use requires that anticipated benefit be weighed against possible fetal hazards. Routine diuretic use in otherwise healthy pregnant women is inappropriate.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Canrenone (active spironolactone metabolite) appears in breast milk and thiazides are excreted in small amounts and may suppress lactation at high doses; use during breastfeeding is not recommended.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hydrochlorothiazide: Inhibits sodium and chloride reabsorption in the cortical diluting segment of the distal renal tubule, increasing sodium and water excretion.
• Spironolactone: Competitive aldosterone antagonist at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted tubule; limits thiazide-induced potassium loss.