سعر ستيرونوميت 4مجم 4 اقراص 2023

Steronomet 4 mg (AVS, Egypt): ondansetron 4 mg tablets, a selective 5-HT3 receptor antagonist antiemetic used to prevent nausea and vomiting.

• Prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy (including cisplatin >= 50 mg/m2)Population: AdultsDailyMed (U.S. National Library of Medicine)
• Prevention of nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer chemotherapyPopulation: Adults and children 4 years and olderDailyMed (U.S. National Library of Medicine)
• Prevention of nausea and vomiting associated with radiotherapy (total body irradiation, single high-dose or daily fractions to the abdomen)Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most common in adults: chemotherapy-induced nausea prevention - headache, malaise/fatigue, constipation, diarrhoea; radiotherapy - headache, constipation, diarrhoea; postoperative - headache and hypoxia. Less common: extrapyramidal reactions, transient transaminase rises, rash.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity (e.g. anaphylaxis) to ondansetron or any component of the formulation.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Concomitant use of apomorphine (risk of profound hypotension and loss of consciousness).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity reactions including anaphylaxis and bronchospasm (also in patients hypersensitive to other 5-HT3 antagonists): discontinue if suspected.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• QT prolongation and torsade de pointes: avoid in congenital long QT syndrome; ECG monitoring with electrolyte abnormalities, heart failure, bradyarrhythmias or other QT-prolonging drugs.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Serotonin syndrome, mainly with concomitant serotonergic drugs (SSRIs, SNRIs, MAOIs, mirtazapine, fentanyl, lithium, tramadol, IV methylene blue); discontinue and treat supportively if it occurs.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• ApomorphineContraindicated: profound hypotension and loss of consciousness reported.DailyMed (U.S. National Library of Medicine)
• Serotonergic drugs (SSRIs, SNRIs, MAOIs, mirtazapine, fentanyl, lithium, tramadol, IV methylene blue)Risk of serotonin syndrome.DailyMed (U.S. National Library of Medicine)
• Other QT-prolonging drugsAdditive QT prolongation; ECG monitoring recommended.DailyMed (U.S. National Library of Medicine)

• Published epidemiological studies on ondansetron and major birth defects report inconsistent findings with important methodological limitations; postmarketing data have not identified a drug-associated risk of miscarriage or adverse maternal outcomes; animal studies showed no fetal harm.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Present at low levels in human milk (relative infant dose about 3.7% after IV doses); unlikely to result in clinically relevant infant exposure at IV doses up to 4 mg/day.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Ondansetron: Blocks 5-HT3 receptors on vagal afferents and in the chemoreceptor trigger zone, suppressing chemotherapy-, radiotherapy- and postoperative nausea/vomiting pathways.