سعر تاناتريل 5مجم 14 اقراص 2022

Imidapril 5 mg tablets, pack of 14, marketed in Egypt by Hikma Pharma (ACE inhibitor antihypertensive).

• Treatment of essential hypertension in adults.Population: AdultsNorthumbria Pharma Ltd (UK MAH)

• Common: cough. Uncommon: headache, dizziness, hypotension, rash, pruritus. Rare: insomnia, dysgeusia, tinnitus, palpitations, nausea, vomiting, diarrhoea, abdominal pain, renal impairment, proteinuria, oedema, fatigue.International label, same formulation · Northumbria Pharma Ltd (UK MAH)

• Hypersensitivity to imidapril, any other ACE inhibitor or excipients; history of ACE-inhibitor angioedema; hereditary/idiopathic angioedema; second and third trimesters of pregnancy; renal failure (CrCl < 10 ml/min); aliskiren in patients with diabetes or GFR < 60 ml/min/1.73 m2; concomitant sacubitril/valsartan.International label, same formulation · Northumbria Pharma Ltd (UK MAH)

• May cause profound hypotension, especially after the first dose in volume-depleted patients or severe heart failure; start with 2.5 mg under close supervision in high-risk patients.International label, same formulation · Northumbria Pharma Ltd (UK MAH)
• Neutropenia/agranulocytosis, thrombocytopenia and anaemia reported rarely with ACE inhibitors; extreme caution in collagen vascular disease, immunosuppression, allopurinol or procainamide treatment, especially with renal impairment.International label, same formulation · Northumbria Pharma Ltd (UK MAH)
• Hyperkalaemia may occur, especially with renal insufficiency, diabetes, potassium-sparing diuretics, potassium supplements or salt substitutes.International label, same formulation · Northumbria Pharma Ltd (UK MAH)

• Potassium-sparing diuretics / potassium supplements / potassium-containing salt substitutesMay cause significant, potentially lethal increases in serum potassium, especially with renal impairment; avoid unless hypokalaemia, and monitor potassium.Northumbria Pharma Ltd (UK MAH)
• Non-potassium-sparing diureticsRisk of sudden hypotension and/or acute renal impairment when starting the ACE inhibitor in salt/volume-depleted patients.Northumbria Pharma Ltd (UK MAH)

• When pregnancy is diagnosed, stop the ACE inhibitor immediately and start alternative therapy if appropriate.International label, same formulation · Northumbria Pharma Ltd (UK MAH)

• Imidapril: Prodrug converted to imidaprilat, which inhibits angiotensin-converting enzyme and reduces angiotensin II formation.