سعر تاركا 180/2مجم ام ار 28 قرص 2022

Fixed-dose combination of verapamil hydrochloride 180 mg (modified release) and trandolapril 2 mg in modified-release tablets (Abbott); pack of 28 tablets.

• Essential hypertension in patients whose blood pressure has been normalised with the individual components in the same dose proportion.Health Products Regulatory Authority (HPRA), Ireland

• Hypersensitivity to trandolapril, any ACE inhibitor or verapamil; history of ACE-inhibitor angioedema or hereditary/idiopathic angioedema; 2nd and 3rd trimester of pregnancy; children <18 years; concomitant IV beta-blockers.International label, same product · Health Products Regulatory Authority (HPRA), Ireland
• Because of verapamil: severe left ventricular dysfunction, hypotension or cardiogenic shock, sick sinus syndrome or 2nd/3rd-degree AV block without a functioning pacemaker.International label, same product · DailyMed (U.S. National Library of Medicine)

• Boxed warning (US): fetal toxicity - discontinue as soon as pregnancy is detected; drugs acting on the renin-angiotensin system can cause fetal injury and death.International label, same product · DailyMed (U.S. National Library of Medicine)
• Angioedema (including intestinal angioedema), hyperkalaemia and renal function deterioration may occur with the ACE-inhibitor component; use caution with first-degree AV block, bradycardia and neuromuscular-transmission disorders.International label, same product · Health Products Regulatory Authority (HPRA), Ireland

• Intravenous beta-blockersMust not be given during Tarka therapy; verapamil plus beta-blockers can cause severe AV-conduction disturbance and bradycardia.Health Products Regulatory Authority (HPRA), Ireland
• Potassium-sparing diuretics / potassium supplementsRisk of hyperkalaemia with the trandolapril component.DailyMed (U.S. National Library of Medicine)

• ACE inhibitors are not recommended in the first trimester and are contraindicated in the 2nd and 3rd trimesters; stop immediately when pregnancy is diagnosed.International label, same product · Health Products Regulatory Authority (HPRA), Ireland
• Use is not recommended during breastfeeding.International label, same product · Health Products Regulatory Authority (HPRA), Ireland

• Verapamil hydrochloride: Inhibits calcium influx in cardiac and vascular smooth muscle; slows AV conduction and reduces myocardial contractility and peripheral resistance.