سعر Taxotere 20mg/ml i.v. infusion 2024

Docetaxel 20 mg/mL concentrate for IV infusion vial (taxane antineoplastic), Sanofi, Egyptian market.

• Breast cancer (metastatic after chemotherapy failure; adjuvant with doxorubicin/cyclophosphamide), non-small cell lung cancer, metastatic castration-resistant prostate cancer, gastric adenocarcinoma and squamous cell carcinoma of the head and neck (in specified regimens).DailyMed (US National Library of Medicine)

• Most common: infections, neutropenia, anemia, febrile neutropenia, hypersensitivity, thrombocytopenia, neuropathy, dysgeusia, dyspnea, constipation, anorexia, nail disorders, fluid retention, asthenia, pain, nausea, diarrhea, vomiting, mucositis, alopecia, skin reactions and myalgia.International label, same formulation · DailyMed (US National Library of Medicine)

• Neutrophil counts < 1,500 cells/mm3; history of severe hypersensitivity to docetaxel or other drugs formulated with polysorbate 80.International label, same formulation · DailyMed (US National Library of Medicine)

• Boxed warning: treatment-related mortality increased with abnormal liver function, higher doses and NSCLC after platinum at 100 mg/m2; avoid if bilirubin > ULN or AST/ALT > 1.5 x ULN with alkaline phosphatase > 2.5 x ULN; severe neutropenia, hypersensitivity and fluid retention.International label, same formulation · DailyMed (US National Library of Medicine)
• Other warnings: enterocolitis/neutropenic colitis, second primary malignancies (AML, MDS, NHL), cutaneous reactions, severe neurosensory symptoms.International label, same formulation · DailyMed (US National Library of Medicine)

• Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin, ritonavir, voriconazole)Avoid concomitant use: may increase docetaxel exposure and toxicity.DailyMed (US National Library of Medicine)

• Docetaxel can cause fetal harm; verify pregnancy status before treatment; females should use effective contraception during treatment and for 2 months after the last dose.International label, same formulation · DailyMed (US National Library of Medicine)
• No data on presence in human milk; advise not to breastfeed during treatment and for 1 week after the last dose.International label, same formulation · DailyMed (US National Library of Medicine)

• Docetaxel: Binds beta-tubulin and enhances polymerization to stable microtubules, inhibiting mitosis (directory pharmacology summary).