سعر اناندرون 50مجم 90 قرص 2022

Nilutamide 50 mg tablets (Anandron brand; company listed as Sanofi), a non-steroidal anti-androgen for prostate cancer; 90 tablets.

• Metastatic prostate cancer, in combination with surgical or chemical castration (efficacy mainly in previously untreated patients)Population: Adult menBase de Données Publique des Médicaments (ANSM / French Ministry of Health)
• Metastatic prostate cancer (stage D2) in combination with surgical castrationPopulation: Adult menDailyMed (U.S. National Library of Medicine)

• Very common: impaired dark adaptation and colour vision (about 25%), transaminase increase, nausea, vomiting, impotence, decreased libido, hot flushes. Common: night blindness, interstitial lung disease, sweating, alopecia, alcohol intolerance. Rare: hepatitis. Very rare: aplastic anaemia. Not known: gynaecomastia, QT prolongation.International label, same formulation · Base de Données Publique des Médicaments (ANSM / French Ministry of Health)

• Hypersensitivity to nilutamide or excipients; severe hepatic impairment; history of nilutamide-related liver injury; severe respiratory insufficiency. Not indicated in women or children.International label, same formulation · Base de Données Publique des Médicaments (ANSM / French Ministry of Health)

• Check transaminases before treatment and periodically; stop treatment if transaminases exceed 3 times the upper limit of normal; patients should report symptoms suggestive of hepatitis (nausea, vomiting, abdominal pain, jaundice, dark urine, pruritus, asthenia, anorexia, flu-like syndrome).International label, same formulation · Base de Données Publique des Médicaments (ANSM / French Ministry of Health)
• Interstitial lung disease (including fatal pulmonary fibrosis) may occur, usually within the first 3 months; investigate acute or worsening dyspnoea, cough or fever, interrupt treatment during investigation and stop permanently if interstitial pneumonitis is found.International label, same formulation · Base de Données Publique des Médicaments (ANSM / French Ministry of Health)
• Androgen deprivation may prolong the QT interval; assess benefit/risk in patients with QT risk factors or on QT-prolonging drugs.International label, same formulation · Base de Données Publique des Médicaments (ANSM / French Ministry of Health)

• Vitamin K antagonistsNilutamide may reduce their hepatic metabolism; monitor prothrombin time/INR closely and reduce the anticoagulant dose if necessary.Base de Données Publique des Médicaments (ANSM / French Ministry of Health)
• Phenytoin, propranolol, chlordiazepoxide, diazepam, theophyllineElimination may be delayed and blood levels increased; dose adjustment may be needed.Base de Données Publique des Médicaments (ANSM / French Ministry of Health)
• QT-prolonging drugs (class IA/III antiarrhythmics, methadone, moxifloxacin, antipsychotics)Evaluate carefully; closely monitor the QT interval.Base de Données Publique des Médicaments (ANSM / French Ministry of Health)

• Pregnancy and breastfeeding: not applicable (product indicated only in men).International label, same formulation · Base de Données Publique des Médicaments (ANSM / French Ministry of Health)

• Nilutamide: Blocks the effects of testosterone at the androgen receptor level (US label).