سعر تينيدون Tenedone‏ 50/25مجم 30 قرص 2026

Fixed-dose combination of atenolol (beta1-selective blocker) and chlorthalidone (thiazide-like diuretic) film-coated tablets marketed in Egypt by Sigma.

• Usually well tolerated; adverse effects are mostly mild and transient and essentially the same as those of the individual components (atenolol and chlorthalidone).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Sinus bradycardia, heart block greater than first degree, cardiogenic shock, overt cardiac failure, anuria, and hypersensitivity to the product or to sulfonamide-derived drugs.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Cardiac failure: beta blockade may depress myocardial contractility and precipitate more severe failure; withdraw if failure persists despite treatment.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Use with caution in impaired renal function (thiazides may precipitate azotemia) and in hepatic impairment (fluid/electrolyte shifts may precipitate hepatic coma).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Calcium channel blockersMay have an additive effect when given with atenolol/chlorthalidone.DailyMed (U.S. National Library of Medicine)
• Catecholamine depletors (e.g., reserpine)Observe closely for hypotension and/or marked bradycardia.DailyMed (U.S. National Library of Medicine)
• LithiumDiuretics reduce lithium renal clearance and add a high risk of lithium toxicity; generally should not be co-administered.DailyMed (U.S. National Library of Medicine)

• Atenolol can cause fetal harm; use starting in the second trimester has been associated with infants small for gestational age; first-trimester fetal injury cannot be excluded.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Atenolol is excreted in breast milk (milk:plasma 1.5-6.8); clinically significant bradycardia reported in breastfed infants; neonates may be at risk of hypoglycemia and bradycardia.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Atenolol: Beta1-selective beta-adrenergic receptor blocker without membrane-stabilizing or intrinsic sympathomimetic activity; selectivity is not absolute at higher doses (US label).
• Chlorthalidone: